Glucocorticoids Regulate the Vascular Remodeling of Aortic Dissection Via the p38 MAPK-HSP27 Pathway Mediated by Soluble TNF-RII

EBioMedicine
Lei ZhangHuiying Sun

Abstract

Increasing researches suggest that inflammatory response is involved in vascular remodeling, which plays an important role in the development of aortic dissection. Glucocorticoids have been widely used in the clinical practice due to its powerful and effective anti-inflammatory property. However, the potential relationship between glucocorticoids and aortic dissection was still obscure. This study sought to elucidate the effect of glucocorticoids on the development and progression of aortic dissection, and the potential mechanism involved. Serum cortisol in aortic dissection patients was significantly higher than that in non-ruptured aortic aneurysm patients and healthy volunteers by radioimmunoassay. In modified C57BL/6 mouse model of aortic dissection, glucocorticoids reduced the incidence of aortic dissection and protected the collagen from degradation. Furthermore, glucocorticoids inhibited the TNF-α secretion of THP-1 monocytes, decreased the migration, phenotype switch from contractile type to synthetic type, and the apoptosis of human aortic smooth muscle cells induced by TNF-α. Finally, TNF-sRII was identified as an important cytokine in cellular interaction that participated in vascular remodeling by targeting the p38 ...Continue Reading

Citations

May 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shih-Hung TsaiYu-Juei Hsu
Mar 3, 2020·Frontiers in Physiology·Xinhao WangWei Guo
Jun 13, 2021·Experimental Cell Research·Xipeng WangXiaoming Zhang
Jul 25, 2021·International Journal of Molecular Sciences·Clare MacLeodMark Nixon

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Methods Mentioned

BETA
dissection
ELISA
Assay
antibody array
flow cytometry

Software Mentioned

Image J
COR image studio
ImageStream
GraphPad
PathScan
LI
image pro - plus
SPSS
Prism

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