Glucocorticoids Suppress the Browning of Adipose Tissue via miR-19b in Male Mice

Endocrinology
Yifan LvGuoxian Ding

Abstract

Physiological levels of glucocorticoids (GCs) are required for proper metabolic control, and excessive GC action has been linked to a variety of pandemic metabolic diseases. MicroRNA (miRNA)-19b plays a critical role in the pathogenesis of GC-induced metabolic diseases. This study explored the potential of miRNA-based therapeutics targeting adipose tissue. Our results showed that overexpressed miR-19b in stromal vascular fraction (SVF) cells derived from subcutaneous adipose tissue had the same effects as dexamethasone (DEX) treatment on the inhibition of adipose browning and oxygen consumption rate. The inhibition of miR-19b blocked DEX-mediated suppression of the expression of browning marker genes as well as the oxygen consumption rate in differentiated SVF cells derived from subcutaneous and brown adipose tissue. Overexpressed miR-19b in SVF cells derived from brown adipose tissue had the same effects as DEX treatment on the inhibition of brown adipose differentiation and energy expenditure. Glucocorticoids transcriptionally regulate the expression of miR-19b via a GC receptor-mediated direct DNA binding mechanism. This study confirmed that miR-19b is an essential target for GC-mediated control of adipose tissue browning. I...Continue Reading

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Citations

Oct 16, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mengge SunSonglin Peng
Oct 13, 2018·Nuclear Receptor Research·Rebecca A LeeJen-Chywan Wang
Feb 10, 2020·Endocrinology·Daniel FergusonCharles A Harris
Apr 12, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Stylianos RavanidisEpaminondas Doxakis

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