Glucocorticosteroids for people with alcoholic hepatitis

The Cochrane Database of Systematic Reviews
Chavdar S PavlovChristian Gluud

Abstract

Alcoholic hepatitis is a form of alcoholic liver disease, characterised by steatosis, necroinflammation, fibrosis, and potential complications to the liver disease. Typically, alcoholic hepatitis presents in people between 40 and 50 years of age. Alcoholic hepatitis can be resolved if people abstain from drinking, but the risk of death will depend on the severity of the liver damage and abstinence from alcohol. Glucocorticosteroids are used as anti-inflammatory drugs for people with alcoholic hepatitis. Glucocorticosteroids have been studied extensively in randomised clinical trials in order to assess their benefits and harms. However, the results have been contradictory. To assess the benefits and harms of glucocorticosteroids in people with alcoholic hepatitis. We identified trials through electronic searches in Cochrane Hepato-Biliary's (CHB) Controlled Trials Register, CENTRAL, MEDLINE, Embase, LILACS, and Science Citation Index Expanded. We looked for ongoing or unpublished trials in clinical trials registers and pharmaceutical company sources. We also scanned reference lists of the studies retrieved. The last search was 20 October 2016. Randomised clinical trials assessing glucocorticosteroids versus placebo or no interve...Continue Reading

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Citations

Apr 10, 2019·The Cochrane Database of Systematic Reviews·Chavdar S PavlovChristian Gluud
Jul 18, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David W CrabbMichael R Lucey
Jul 10, 2020·The Kaohsiung Journal of Medical Sciences·Bo DuHai-Feng Zhang
Jul 1, 2020·Terapevticheskiĭ arkhiv·C S PavlovC Gluud

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