Glucocorticosteroids inhibit leukotriene production

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
I C CrockerR G Townley

Abstract

The mode of action of corticosteroids, important drugs in the treatment of inflammatory disease, is not yet fully understood. Corticosteroids are known to inhibit phospholipase A2 in unprimed eosinophils and basophils, preventing leukotriene synthesis, but their effect on cells that are already primed is unknown. As inflammatory cells from atopic subjects are often primed in vivo, we studied the effects of two potent corticosteroids on basophil sulfidoleukotriene production in peripheral blood mixed leukocytes (PBML) from in-season and out-of-season atopic individuals. Cells were incubated for 24 hours with mometasone furoate or beclomethasone dipropionate, primed with IL-3, stimulated with calcium ionophore, buffer, allergen or anti-IgE, and leukotriene production was quantified. Peripheral blood mononuclear leukocytes from five of ten donors (in season) produced elevated sulfidoleukotrienes without a stimulus; cells from seven donors responded to anti-IgE by increased sulfidoleukotrienes. Neither steroid consistently affected sulfidoleukotriene production in anti-IgE-stimulated cells which were releasing sulfidoleukotrienes in the absence of a stimulant. In comparison, sulfidoleukotriene production was significantly reduced b...Continue Reading

References

May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S L Hong, L Levine
Jan 1, 1992·International Archives of Allergy and Immunology·S HaisaR G Townley
Jan 1, 1991·Annals of the New York Academy of Sciences·D J Margolskee
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S C BischoffC A Dahinden
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T ShinomuraY Nishizuka
Jan 1, 1991·Immunopharmacology and Immunotoxicology·B E BartonM I Siegel
Jan 1, 1991·Annals of the New York Academy of Sciences·L M Lichtenstein, B S Bochner
Jan 1, 1985·International Archives of Allergy and Applied Immunology·R P SchleimerL M Lichtenstein
Jan 1, 1983·Prostaglandins·D F WoodwardM A Wasserman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Jan 1, 1980·Immunological Reviews·K A Smith
Jan 1, 1994·Drugs·N Chanarin, S L Johnston
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·W S PowellJ G Martin

❮ Previous
Next ❯

Citations

Aug 2, 2000·Pediatric Pulmonology·H Bisgaard
May 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A S NayakJ E Harrison
May 7, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Peter CreticosPaul Dorinsky
May 10, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·B O'ConnorB N Lutsky
Dec 2, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K T KimK Rickard
Jul 1, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I C CrockerR G Townley
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Adam AntczakPeter J Barnes
May 1, 2008·AAPS PharmSciTech·Naazneen SurtiAmbikanandan Misra
Sep 1, 2001·The American Journal of Medicine·R A NathanUNKNOWN Fluticasone Propionate Study Group
Oct 10, 2007·Current Medical Research and Opinion·Jill P Karpel, Harold Nelson
Jul 11, 2002·The American Journal of Medicine·John H BrabsonKathleen Rickard
Jun 15, 2011·Immunopharmacology and Immunotoxicology·Hyun-A OhHyun-Ja Jeong
Apr 24, 2002·Pulmonary Pharmacology & Therapeutics·Shelby P UmlandSebastian L Johnston
Jan 18, 2011·Experimental Biology and Medicine·Hyun-A OhHyung-Min Kim
Apr 6, 2019·Minerva anestesiologica·Undurti N Das
Jan 12, 2000·The Annals of Pharmacotherapy·K V Blake
Aug 10, 2019·Frontiers in Immunology·Cindy StrehlFrank Buttgereit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Related Papers

American Journal of Respiratory and Critical Care Medicine
P J BarnesW W Busse
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
K T KimK Rickard
The American Review of Respiratory Disease
R DjukanovićS T Holgate
© 2021 Meta ULC. All rights reserved