PMID: 616367Oct 23, 1977Paper

Gluconeogenesis in kidney cortex slices of the guinea pig. Its relation to acidosis and to calcium

Current Problems in Clinical Biochemistry
B Stumpf, H Kraus

Abstract

In contrast to rat kidney cortex the glucogenic capacity of kidney cortex slices from normally treated guinea pigs was very low. Reduction of the pH of the incubation medium by either lowering the HCO3-concentration or by increasing the pCO2 resulted only in varying stimulatory effects on glucose production from endogeneous or exogeneous sources. Considerable rates of net synthesis of glucose from lactate, pyruvate, malate, 2-oxoglutarate, glutamate, and glycerol--but not from glutamine--were only observed in kidneys from animals with prolonged metabolic acidosis. Neither in experiments with normally treated animals nor in those with acidotic guinea pigs the glucose production decreased, when calcium was omitted from the incubation medium. Though glutamine was not converted into glucose, it served as a substrate for ammoniagenesis. On the basis of the presented results it is concluded that species differences exist in the regulation of renal gluconeogenesis.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.