Nov 1, 1977

Gluconeogenesis in the liver of rats receiving 1,3-butanediol in their diet

Voprosy pitaniia
N N VelikiĭT M Kuchmerovskaia

Abstract

Inclusion of 1,3-butandiol as a synthetic source of nutritional energy into the composition of a low-carbohydrate diet produced a fall in the ration of free [NAD+]:[NADN] and [NADP]:[NADPN] calculated for the cytoplasm and mitochondria of the liver cell in rats according to the concentration of oxidated and reduced metabolites and the equilibrium constant of the lactate-dehydrogenase, glutamate-dehydrogenase and malic-fermentative systems. In these conditions the concentration of metabolites, at whose level the conjugation of the carbohydrates decomposition during glycolysis and their synthesis at the time of gluconeogenesis (phosphoenol-pyruvate, malate, oxaloacetate) is realized, as well as the activity of key gluconeogenesis enzymes (phosphoenol-pyruvate carboxykinase, fructose-1,6-diphosphatase) increase. The NADN generation in the course of oxidative metabolism of 1,3-butandiol gives rise to reducing properties of the free NAD-par cytoplasm and mitochondria pool, which leads to the intensification of gluconeogenesis in the liver, attended by a drop of the phosphate potential level.

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Mentioned in this Paper

Pars Planitis
Carbohydrate nutrients
Butylene Glycols
Conjugation
Diet
Oxaloacetates
Lactate
Dietary Carbohydrates
Gluconeogenesis
Enzymes, antithrombotic

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