PMID: 18720742Aug 30, 2008Paper

Glucoregulation in normal weight schizophrenia patients treated by first generation antipsychotics

Srpski arhiv za celokupno lekarstvo
Nadja MarićVera Popovic

Abstract

Schizophrenia patients are at greater risk of obesity, diabetes mellitus (DM), lipid abnormalities and cardiovascular disorders. The metabolic complications in patients are associated with several risk factors: family history of DM, lifestyle, smoking, dietary habits, physical inactivity, but also with antipsychotic medication. In literature, most publications have been focused on the effects of the second generation antipsychotics (SGA) on glucose metabolism. However, less attention has been paid to abnormality in glucoregulation, patients with schizophrenia treated with the first generation antipsychotics (FGA). The present study evaluated glucose metabolism in normal weight schizophrenia patients treated with FGA. The cross-sectional study included 18 patients (FGA treated) and 20 healthy controls with neither group differences in sex distribution, age, nor in BMI. Inclusion criteria were normal BMI (20-25 kg/m2). The glucose levels, insulin levels and growth hormone levels during oral glucose tolerance test (OGTT) were measured. Fasting glucose and insulin levels did not differ significantly between groups. Groups differed in OGTT glucose and insulin peak and area under curve (AUC), level of significance p < 0.05 (patients ...Continue Reading

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Citations

Jan 22, 2013·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani

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