Glucose- and pH-responsive nanogated ensemble based on polymeric network capped mesoporous silica

ACS Applied Materials & Interfaces
Lei TanRen-Xi Zhuo

Abstract

In this paper, a glucose and pH-responsive release system based on polymeric network capped mesoporous silica nanoparticles (MSN) has been presented. The poly(acrylic acid) (PAA) brush on MSN was obtained through the surface-initiated atom transfer radical polymerization (SI-ATRP) of t-butyl acrylate and the subsequent hydrolysis of the ester bond. Then the PAA was glycosylated with glucosamine to obtain P(AA-AGA). To block the pore of silica, the P(AA-AGA) chains were cross-linked through the formation of boronate esters between 4,4-(ethylenedicarbamoyl)phenylboronic acid (EPBA) and the hydroxyl groups of P(AA-AGA). The boronate esters disassociated in the presence of glucose or in acidic conditions, which lead to opening of the mesoporous channels and the release of loaded guest molecules. The rate of release could be tuned by varying the pH or the concentration of glucose in the environment. The combination of two stimuli exhibited an obvious enhanced release capacity in mild acidic conditions (pH 6.0).

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Citations

Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Tao WuBin Shi
May 20, 2016·Chemical Communications : Chem Comm·Li ZhaoJianxun Ding
May 24, 2016·ACS Applied Materials & Interfaces·Dongjian ShiMitsuru Akashi
May 28, 2016·ACS Applied Materials & Interfaces·Dan ZhaoFeng Li
Aug 30, 2017·Chemical Society Reviews·Jia WenShiguo Sun
Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Jul 4, 2017·Particle & Particle Systems Characterization : Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems·Yangyang LiChuanbin Mao
Sep 28, 2017·Bioengineering·Miguel Gisbert-GarzaránMaría Vallet-Regí
Feb 9, 2017·Journal of Experimental & Clinical Cancer Research : CR·Shoubing ZhouYanwen Liu
Apr 30, 2019·Small·Andrea BernardosRamón Martínez-Máñez
Apr 27, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Yuya IshizakiMasaya Mitsuishi
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajesh SalveWassana Yantasee
Oct 11, 2019·Accounts of Chemical Research·Alexandra StubeliusAdah Almutairi

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