Glucose-6-phosphate dehydrogenase deficiency in India

Indian Journal of Pediatrics
Dipika MohantyRoshan B Colah

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest red cell enzymopathy in humans and has an X-linked inheritance. It has been reported from India more than 30 years ago and the prevalence varies from 0-27% in different caste, ethnic and linguistic groups. The major clinical manifestations are drug induced hemolytic anemia, neonatal jaundice and chronic non-spherocytic hemolytic anemia. Individuals with G6PD deficiency have a selective advantage against falciparum malaria. Thirteen biochemically characterized variants have been reported from India. At the molecular level, G6PD Mediterranean is the most common deficient variant in the caste groups whereas, G6PD Orissa is more prevalent among the tribal of India. The third common variant seen in India is G6PD Kerala-Kalyan.

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Citations

May 19, 2012·Paediatrics and International Child Health·Y R Bhat, C G Pavan Kumar
Jun 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Chun DengJia-Lin Yu
Feb 18, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Srinivas MurkiGurjeevan Garewal
Apr 22, 2011·International Journal of Laboratory Hematology·B MoizM Khurshid
Nov 28, 2006·Indian Journal of Pediatrics·Prabhakar S KedarDipika Mohanty
Sep 3, 2011·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·A M Shanthala DeviRameshkumar Karuna
Nov 8, 2005·Indian Journal of Pediatrics·Mritunjay PaoSaroja Balan
Feb 8, 2013·European Journal of Clinical Nutrition·H P S Sachdev, T Gera
Aug 14, 2020·Malaria Journal·Baburam MarasiniBhim Prasad Acharya
May 20, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Arun Kumar ArunachalamEunice S Edison
Dec 11, 2019·Journal of Tropical Pediatrics·Anitha KommalurGayathri Devi Chinnappa
Apr 23, 2013·Indian Journal of Pediatrics·R Kishore KumarEnzo Ranieri
Apr 8, 2010·Indian Pediatrics·Seema Kapoor, Madhulika Kabra

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