PMID: 11903742Mar 21, 2002Paper

Glucose-6-phosphate dehydrogenase deficiency is associated with increased initial clinical severity of acute viral hepatitis A

Journal of Gastroenterology and Hepatology
I Gotsman, M Muszkat

Abstract

In glucose-6-phosphate dehydrogenase (G6PD) deficiency, the enzyme is deficient in liver cells as well as in erythrocytes. It has been suggested that this may be associated with a more severe clinical presentation of acute viral hepatitis A. The aim of this study is to determine the severity of liver disease in patients with viral hepatitis and G6PD deficiency. Eighteen patients with diagnosed G6PD deficiency and acute hepatitis A were compared with 18 matched control patients with hepatitis A in a university hospital for liver disease severity and clinical outcome. Two of 18 patients with G6PD deficiency had neurological deterioration. Patients with G6PD deficiency had a mean peak prothrombin time (PT) that was significantly prolonged as compared with the control group (15.5 +/- 3.7 vs 12.9 +/- 2.0 s, respectively, P < 0.02), and a significantly higher proportion had an abnormal PT (PT > 13.3 s): 61 versus 11% (P < 0.0001). Hemolysis occurred in 44% of the G6PD deficiency patients. Total and direct bilirubin were significantly higher in all patients with G6PD deficiency, including patients without hemolysis. There was no significant difference in liver enzyme levels between the two groups. Patients with G6PD deficiency had a l...Continue Reading

References

Jan 29, 1966·Lancet·C ChoremisE Gavriilidou
Jun 1, 1968·Annals of Internal Medicine·R H MorrowJ H Edgcomb

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Citations

Aug 8, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ajay K JainFatema Chahwala
Feb 14, 2008·The Journal of Infectious Diseases·Yi-Hsuan WuDaniel Tsun-Yee Chiu
Oct 24, 2003·The Journal of the Association of Nurses in AIDS Care : JANAC·Kenneth D Phillips, Robyn Brewer
Nov 2, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jun ZhaoXu Ma
Dec 21, 2007·The Korean journal of laboratory medicine·Dong Wook JekarlChong-Won Park
Apr 21, 2018·Annals of Hematology·Adrià CarpioJavier Fernández
Apr 4, 2019·BMC Research Notes·Stephanie M LaudenTroy C Lund
Jun 12, 2020·International Journal of Molecular Sciences·Paola ChecconiLucia Nencioni
Oct 9, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Dhruva SharmaShashank Shekhar

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