Glucose-6-phosphate dehydrogenase deficient red cells: resistance to infection by malarial parasites

Science
L LuzzattoS Reddy

Abstract

Erythrocyte mosaicism occurs in females heterozygous for glucose-6-phosphate dehydrogenase deficiency. In blood from female children with acute Plasmodium falciparum malaria the parasite rate was 2 to 80 times higher in normal than in deficient erythrocytes. This may be the mechanism whereby the gene for glucose-6-phosphate dehydrogenase deficiency confers selective advantage against malaria to heterozygous females, and thus may have attained the polymorphic frequency occurring in populations living in areas with endemic malaria.

References

Dec 21, 1965·Biochemical and Biophysical Research Communications·L Luzzatto, N C Allan
Aug 1, 1958·The Journal of Clinical Investigation·R T GROSSP A MARKS
May 9, 1959·Nature·S P MANDEL
May 13, 1961·British Medical Journal·A C ALLISON, D F CLYDE
Apr 1, 1961·Annals of Tropical Medicine and Parasitology·H M GILLES, B G TAYLOR
Jan 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·E BEUTLERV F FAIRBANKS
Sep 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R G DAVIDSONB CHILDS
Jan 1, 1964·Cold Spring Harbor Symposia on Quantitative Biology·W E NANCE
May 1, 1965·The American Journal of Tropical Medicine and Hygiene·R D POWELL, G J BREWER
Jun 1, 1958·Proceedings of the National Academy of Sciences of the United States of America·P A MarksE Hirschberg
Jul 1, 1949·Transactions of the Royal Society of Tropical Medicine and Hygiene·J W FIELD

❮ Previous
Next ❯

Citations

Jan 1, 1988·Molecular Biology Reports·A H BeamontA J Vermorken
Feb 1, 1988·Biochemical Genetics·W PretschS Merkle
Sep 18, 2007·Parasitology Research·Kanjaksha Ghosh, Kinjalka Ghosh
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·D I ThurnhamR Bull
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Kaikai, D I Thurnham
Sep 1, 1983·Molecular and Biochemical Parasitology·T G GearyJ B Jensen
Mar 24, 2004·International Journal for Parasitology·Katja BeckerHagai Ginsburg
Sep 4, 1976·Lancet·D BurnettA R Bradwell
Sep 4, 1976·Lancet·L LuzzattoA I Williams
Jun 2, 1979·Lancet·L Luzzatto, U Bienzle
Mar 20, 2003·Mutation Research·Newton E Morton
Jun 24, 1976·The New England Journal of Medicine·J F Desforges
Jul 8, 1976·The New England Journal of Medicine·J F Desforges, F Quimby
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G ModianoL Luzzatto
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E F RothR L Nagel
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M A Chappell, L R Snyder
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Kristen M MassimineKaren S Anderson
Nov 1, 1969·British Medical Journal
Oct 1, 1978·Journal of Medical Genetics·E BottiniG Maggioni
Jun 24, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anna L Peters, Cornelis J F Van Noorden
Mar 21, 2009·PLoS Computational Biology·Pedro M B M CoelhoMichael A Savageau
Apr 1, 1996·Emerging Infectious Diseases·B R Levin
Nov 22, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Lucio Luzzatto
Aug 19, 2007·Journal of Postgraduate Medicine·V Tripathy, B M Reddy
Feb 14, 2004·Redox Report : Communications in Free Radical Research·David J Roberts, Thomas N Williams
Oct 22, 2013·Journal of Proteomics·José M BautistaAntonio Puyet
Oct 15, 1975·Experientia·J E Huheey, D L Martin
May 3, 2005·Toxicological Reviews·Marco L A Sivilotti
Jul 6, 1971·Annals of the New York Academy of Sciences·A G MotulskyG Stamatoyannopoulos
Oct 1, 1995·European Journal of Epidemiology·S Muntoni
Jun 22, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·R D Theakston, K A Fletcher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.