Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling

American Journal of Physiology. Endocrinology and Metabolism
Katrine D GalsgaardJens J Holst

Abstract

Glucagon and insulin are important regulators of blood glucose. The importance of insulin receptor signaling for alpha-cell secretion and of glucagon receptor signaling for beta-cell secretion is widely discussed and of clinical interest. Amino acids are powerful secretagogues for both hormones, and glucagon controls amino acid metabolism through ureagenesis. The role of insulin in amino acid metabolism is less clear. Female C57BL/6JRj mice received an insulin receptor antagonist (IRA) (S961; 30 nmol/kg), a glucagon receptor antagonist (GRA) (25-2648; 100 mg/kg), or both GRA and IRA (GRA + IRA) 3 h before intravenous administration of similar volumes of saline, glucose (0.5 g/kg), or amino acids (1 µmol/g) while anesthetized with isoflurane. IRA caused basal hyperglycemia, hyperinsulinemia, and hyperglucagonemia. Unexpectedly, IRA lowered basal plasma concentrations of amino acids, whereas GRA increased amino acids, lowered glycemia, and increased glucagon but did not influence insulin concentrations. After administration of GRA + IRA, insulin secretion was significantly reduced compared with IRA administration alone. Blood glucose responses to a glucose and amino acid challenge were similar after vehicle and GRA + IRA administ...Continue Reading

References

Jun 1, 1989·Trends in Pharmacological Sciences·A DeBlasiH J Motulsky
Sep 1, 1985·Endocrinology·D G PipeleersM Van de Winkel
Oct 26, 1974·Lancet·F P AlfordA V Schally
Sep 1, 1972·The Journal of Clinical Investigation·D M RochaR H Unger
May 1, 1969·The Journal of Clinical Investigation·R H UngerA M Eisentraut
Mar 1, 1984·The Journal of Clinical Investigation·G BodenO E Owen
Dec 1, 1994·Metabolism: Clinical and Experimental·P J FlakollN N Abumrad
Jul 1, 1996·The Journal of Clinical Investigation·M R CharltonK S Nair
Aug 28, 1965·Lancet·E SAMOLSV MARKS
Feb 26, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D PomplunM Ristow
Jan 31, 2007·Endocrine Reviews·Jesper GromadaClaes B Wollheim
Sep 11, 2008·Biochemical and Biophysical Research Communications·Lauge SchäfferJeppe Sturis
Jan 5, 2012·The Journal of Clinical Investigation·Roger H Unger, Alan D Cherrington
Jan 10, 2013·PloS One·Louise KnudsenPierre De Meyts
Dec 26, 2013·Diabetes Research and Clinical Practice·Erik Gylfe, Patrick Gilon
Oct 21, 2015·Animals : an Open Access Journal From MDPI·Robert E Meyer
Jun 2, 2016·American Journal of Physiology. Endocrinology and Metabolism·Nicolai J Wewer AlbrechtsenJens J Holst
Aug 30, 2016·Biochemical Pharmacology·Helle A HassingMette M Rosenkilde
Sep 27, 2016·Cell Metabolism·Yurong XinJesper Gromada
Sep 27, 2016·Cell Metabolism·Åsa SegerstolpeRickard Sandberg
Oct 28, 2016·Cell Systems·Mauro J MuraroAlexander van Oudenaarden
Jan 25, 2017·Proceedings of the National Academy of Sciences of the United States of America·Haruka OkamotoJesper Gromada
Mar 23, 2017·Endocrinology·Jens Juul HolstPedro L Herrera
Oct 4, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nicolai J Wewer AlbrechtsenTina Vilsbøll
Oct 6, 2017·American Journal of Physiology. Endocrinology and Metabolism·Katrine D GalsgaardJens J Holst

❮ Previous
Next ❯

Citations

Apr 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Katrine D GalsgaardJens J Holst
Mar 17, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Katrine D GalsgaardJens J Holst
Mar 29, 2019·Endocrine Reviews·Nicolai J Wewer AlbrechtsenJens J Holst
Nov 27, 2020·Diabetes·Nadejda Bozadjieva KramerErnesto Bernal-Mizrachi
Sep 24, 2020·Endocrinology·Kimberley ElJonathan E Campbell
Sep 17, 2020·Molecular Metabolism·Marie Winther-SørensenNicolai J Wewer Albrechtsen
Aug 3, 2021·Journal of the Endocrine Society·Sasha A S KjeldsenNicolai J Wewer Albrechtsen
Sep 7, 2021·American Journal of Physiology. Endocrinology and Metabolism·Nicolai J Wewer Albrechtsen
Oct 19, 2021·American Journal of Physiology. Endocrinology and Metabolism·Jon D AdamsAdrian Vella

❮ Previous
Next ❯

Datasets Mentioned

BETA
E-MTAB-5061

Methods Mentioned

BETA
transfection
PCR
enzyme-linked immunosorbent assays

Software Mentioned

GraphPad
EliteForsk
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.