PMID: 8206564Jun 1, 1994Paper

Glucose and insulin levels during diuretic therapy in hypertensive men

Hypertension
David SiegelS Haffner

Abstract

We investigated serum glucose and insulin levels resulting from thiazide or thiazide-like diuretic administration and determined whether they were associated with serum or intracellular potassium or magnesium values. We also explored the role of obesity both alone and with thiazides on serum insulin and glucose. Hypertensive men were withdrawn from diuretics and repleted with oral potassium and magnesium and then randomized to 2 months of treatment with (1) hydrochlorothiazide, (2) hydrochlorothiazide with oral potassium, (3) hydrochlorothiazide with oral potassium and magnesium (4) hydrochlorothiazide and triamterene, (5) chlorthalidone, or (6) placebo. Serum was available from 202 participants for insulin and glucose determinations. Mean fasting serum glucose and insulin did not change significantly after 2 months of randomized therapy with the exception of participants randomized to chlorthalidone, who had significant increases in both serum insulin and glucose (P < .05 and P < .01, respectively). As body mass index increased, there was a corresponding increase in serum insulin and to a lesser degree in serum glucose. Also, as body mass index increased, participants taking hydrochlorothiazide had a corresponding increase of ...Continue Reading

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Citations

Mar 29, 2008·Metabolic Syndrome and Related Disorders·David Siegel, A L Swislocki
Feb 17, 2010·Metabolic Syndrome and Related Disorders·David Siegel, A L Swislocki
Nov 5, 2008·Hypertension·Tariq ShafiRulan S Parekh
Jan 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Dileep V MenonWanpen Vongpatanasin
Nov 10, 2005·The Journal of Clinical Hypertension·Barry L Carter, Jan Basile
Dec 28, 2004·The American Journal of Cardiology·John B KostisSHEP Collaborative Research Group
May 30, 2014·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Mar 12, 2020·Journal of General Internal Medicine·Jill J HallJohn-Michael Gamble

Related Concepts

Blood Glucose
Thalitone
Diuretic Effect
Electrolytes
Sectrazide
Hypertensive Disease
Novolin
Intracellular Membranes
Obesity
Multivariate Analysis

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