PMID: 6987121Apr 1, 1980Paper

Glucose and insulin responses to oral glucose in overt non-insulin-dependent diabetics with and without the islet cell antibody

Diabetes
R S GrayL J Duncan

Abstract

Plasma insulin, glucose, and insulin/glucose responses to a 50-g oral glucose tolerance test (OGTT) were compared in 14 islet cell antibody (ICAb) positive non-insulin-dependent diabetics (NIDDM), 14 matched ICAb negative NIDDM, and 14 ICAb negative nondiabetic controls. Both groups of NIDDM exhibited marked carbohydrate intolerance with insulinopenia. Despite having significantly higher plasma glucose concentrations during the study, the ICAb positive NIDDM had significantly lower insulin levels, and thus lower insulin/glucose ratios, than the ICAb negative NIDDM both in the fasting state and in response to the OGTT. Similarily, ICAb positive NIDDM had higher integrated glucose responses (delta G), lower integrated insulin responses (delta I), and lower delta I/delta G values than ICAb negative NIDDM. Three ICAb negative and seven ICAb positive NIDDM subsequently required insulin treatment. These findings show that ICAb positive NIDDM suffer from a greater disturbance of B-cell function than do matched ICAb negative NIDDM.

Citations

Oct 1, 1990·Metabolism: Clinical and Experimental·P CohenE Karnieli
Jul 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·A M JenningsJ D Ward
Feb 1, 1983·European Journal of Clinical Investigation·P E Cryer
Jan 1, 1981·The American Journal of Medicine·J Nerup, A Lernmark
Mar 3, 1999·Autoimmunity·R Juneja, J P Palmer
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·R Gregory, R B Tattersall
Nov 1, 1996·Journal of Clinical Nursing·S P Wainwright, D Gould
Apr 1, 1994·Diabetes/metabolism Reviews·A E PontiroliG Pozza

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.