Glucose and lactate regulate maitotoxin-activated Ca2+ entry in spermatogenic cells: the role of intracellular [Ca2+

FEBS Letters
J G ReyesClaudia L Treviño

Abstract

Maitotoxin (MTX), a potent polyether marine biotoxin, induces Ca(2+) entry in different mammalian cells by activation of Ca(2+) channels. The identity and modulation of the MTX-activated Ca(2+) entry pathway is not known. In this work, we show, for the first time, that glucose and lactate can modulate the excitability of spermatogenic cell MTX-activated Ca(2+) channels. Physiological and pharmacological evidences indicate that glucose and lactate differentially affect MTX-activated Ca(2+) entry mainly through changes that these substrates induce on intracellular Ca(2+) stores and the concentration of intracellular Ca(2+) ([Ca(2+)](i)) in spermatogenic cells. Our findings strongly suggest that MTX-activated Ca(2+) channels in spermatogenic cells can be regulated by a Ca(2+)-CaM-dependent protein kinase.

References

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Citations

Dec 18, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·José A PinoJuan G Reyes
Oct 12, 2012·Oxidative Medicine and Cellular Longevity·Juan G ReyesRicardo D Moreno
Jul 8, 2014·Chemical Research in Toxicology·Victor MartinLuis M Botana
Jul 21, 2017·Marine Drugs·Yuri B Shmukler, Denis A Nikishin
Oct 21, 2011·Physiological Reviews·Alberto DarszonClaudia L Treviño

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