Glucose attenuation of atropine-induced deficits in paradoxical sleep and memory

Brain Research
W S StoneP E Gold

Abstract

When administered systemically, glucose attenuates deficits in memory produced by several classes of drugs, including cholinergic antagonists and opiate agonists. Glucose also enhances memory in aged rats, mice, and humans. In addition, glucose ameliorates age-related reductions in paradoxical sleep. Because deficits in paradoxical sleep are most marked in those individual aged rats that also have deficits in memory, treatments which improve one of these functions may similarly improve the other. The present experiments show that glucose attenuates deficits in paradoxical sleep and memory after atropine administration, with similar dose-response curves for both actions. In the first experiment, rats received saline, atropine (1 mg/kg), glucose (100 mg/kg) or combinations of atropine + glucose (10, 100, 250, and 500 mg/kg) 30 min before assessment on a spontaneous alternation task. In the second experiment, 3-h EEGs were assessed for spontaneous daytime sleep in rats administered saline, atropine (1 mg/kg), glucose (100 mg/kg) or combinations of atropine + glucose (10, 100 and 250 mg/kg). In both experiments, glucose significantly attenuated deficits at an optimal dose of 100 mg/kg. A third experiment assessed blood glucose leve...Continue Reading

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Citations

Jan 1, 1992·Behavioral and Neural Biology·W S StoneP E Gold
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M E RagozzinoP E Gold
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E C McNay, P E Gold
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C McNayP E Gold
Apr 13, 2001·Neurobiology of Learning and Memory·T M BlakeM B Parent
Jun 30, 2000·Neurobiology of Learning and Memory·Y Okaichi, H Okaichi
Jan 16, 1999·Neurobiology of Learning and Memory·M M BocciaC M Baratti
Aug 30, 2014·Journal of Physiology, Paris·R Moraga-AmaroJ Stehberg
Oct 5, 2010·Neuroscience and Biobehavioral Reviews·Michael A SmithJonathan K Foster
Feb 19, 2013·Behavioural Brain Research·Leslie A SanduskyEwan C McNay
Apr 30, 2011·Neurobiology of Learning and Memory·William S Stone, Xiaolu Hsi
Nov 18, 2005·Behavioural Brain Research·Jason C PychPaul E Gold
Apr 20, 2004·European Journal of Pharmacology·Bruce S McEwen, Lawrence P Reagan
Aug 24, 2007·Behavioral and Cognitive Neuroscience Reviews·Ewan C McNay, Paul E Gold
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G MehlhornR Schliebs
Jan 29, 2000·Neuroscience and Behavioral Physiology·V I Arkhipov

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