Glucose consumption was measured in the cerebral cortex of rats, anesthetized with 70% N20, under normoxic conditions, as well as in hypoxia (Pao2 about 25 mmHg) and hypercapnia (Paco2 80-85 mmHg). The method used was that Hawkins et al (1974), modified to allow studies of transients in glycolytic rate. Cortical glucose consumption in normoxia was 0.77 mumol-g(-1)-min(-1). It is concluded that whereas glucose consumption in the whole brain of unanesthetized rat may be close to 0.6 mumol-g(-1)-min(-1), that of the cerebral cortex is close to 0.8 mumol-g(-1)-min(-1). During the first 2 min of hypoxia, glucose consumption was increased to twice the normal, and during the fist 2 min of hypercapnia, the corresponding value was less thane third of the normal. After 15 min of hypoxia, the glucose consumption had returned towards control values. In "steady state" hypercapnia, the glycolytic flux was higher than in the inital phase although still below normocapnic values.
Effects of hypoxia of 10-45 seconds duration on energy metabolism in the cerebral cortex of unanesthetized and anesthetized rats
Respiratory insufficiency syndrome (RIS) in preterm infants with gestational age of 32 weeks and less. Neonatal management and follow-up study
Activities of hexokinase, phosphofructokinase, 3-oxo acid coenzyme A-transferase and acetoacetyl-coenzyme A thiolase in nervous tissue from vertebrates and invertebrates
RATE OF UTILIZATION OF GLUCOSE AND 'COMPARTMENTATION' OF ALPHA-OXOGLUTARATE AND GLUTAMATE IN RAT BRAIN
Metabolic assessment of a neuron-enriched fraction of rat cerebrum using high-resolution 1H and 13C NMR spectroscopy
Effect of hypoxia on protein composition of synaptic plasma membranes from cerebral cortex during aging
Protective effect of cyclohexyladenosine on adenosine A1-receptors, guanine nucleotide and forskolin binding sites following transient brain ischemia: a quantitative autoradiographic study
Effects of transient forebrain ischemia and reperfusion on function of dopaminergic neurons and dopamine reuptake in vivo in rat striatum
Astroglial expression of ATL-derived factor, a human thioredoxin homologue, in the gerbil brain after transient global ischemia
Prognostic value of early cortical somatosensory evoked potentials after resuscitation from cardiac arrest
Brain temperature and the neuroprotective action of enadoline and dizocilpine in the gerbil model of global ischaemia
The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia
The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia
A new gerbil model of hindbrain ischemia by extracranial occlusion of the bilateral vertebral arteries
Behavioural, electroencephalographic and neuropathological effects of the intrahippocampal injection of the venom of the South American rattlesnake (Crotalus durissus terrificus)
Ontogenetic differences in energy metabolism and inhibition of protein synthesis in hippocampal slices during in vitro ischemia and 24 h of recovery
Regional differences in the effects of insulin-induced hypoglycemia on phospholipid metabolism of rat brain
A correlative study on hippocampal cation shifts and amino acids and clinico-pathological data in Alzheimer's disease
Regional cerebral glucose metabolic rate during thirty minutes hypoxia of 7% oxygen in adult conscious rats
Glutamate decarboxylase-immunoreactive neurons in the aging rat hippocampus are more resistant to ischemia than CA1 pyramidal cells
NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats
Comparison of carbon monoxide and nitrogen induced effects on synaptic transmission in the rat hippocampal slice
Loss of radioactive 2-deoxy-D-glucose-6-phosphate from brains of conscious rats: implications for quantitative autoradiographic determination of regional glucose utilization
Status epilepticus: the reversibility of calcium loading and acute neuronal pathological changes in the rat hippocampus
Injections of picrotoxin and bicuculline into the amygdaloid complex of the rat: an electroencephalographic, behavioural and morphological analysis
Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy
Inability to verify parasagittal cerebral injury as a neuropathologic entity in the asphyxiated term neonate
Marked anemic hypoxia deteriorates cerebral hemodynamics and brain metabolism during massive intracerebral hemorrhage
Anemic hypoxia in moderate intracerebral hemorrhage: the alterations of cerebral hemodynamics and brain metabolism
Protective effects of vanoxeamine (GBR 12909) against ischaemia-induced hyperactivity and neurodegeneration in the gerbil model of cerebral ischaemia
Neuronal degeneration and microglial reaction in the fetal and postnatal rat brain after transient maternal hypoxia
Necrosis of the substantia nigra, pars reticulate, in flurothyl-induced status epilepticus is ameliorated by the spin trap alpha phenyl-N-tert-butyl nitrone
Effects of a novel arginine-vasopressin derivative, NC-1900, on the spatial memory impairment of rats with transient forebrain ischemia
Cerebral blood flow and metabolic rate in the conscious, freely moving rat: the effects of hypercapnia, and acute ethanol administration
Influence of phenobarbital on changes in the metabolites of the energy reserve of the cerebral cortex following complete ischemia
Local cerebral glucose consumption in the artificially ventilated rat: influence of nitrous oxide analgesia and of phenobarbital anesthesia
Local cerebral glucose consumption during insulin-induced hypoglycemia, and in the recovery period following glucose administration
Regional cerebral glucose utilization in immature fetal guinea pigs during maternal isocapnic hypoxemia
Effects of 1,3-di-o-tolylguanidine (DTG), a sigma ligand, on local cerebral glucose utilization in rat brain
The flux from glucose to glutamate in the rat brain in vivo as determined by 1H-observed, 13C-edited NMR spectroscopy
Effects of MK-801 upon local cerebral glucose utilisation in conscious rats and in rats anaesthetised with halothane
Role of nitric oxide in regulating cerebrocortical oxygen consumption and blood flow during hypercapnia
Rapid feasibility studies of tracers for positron emission tomography: high-resolution PET in small animals with kinetic analysis
Effects of moderate hypoxemia and unilateral carotid ligation on cerebral glucose metabolism and acid-base balance in the rat
Effects of ethanol and temperature on glucose utilization in the in vivo and isolated perfused mouse brain
Metabolism of [1-13C]glucose in a synaptosomally enriched fraction of rat cerebrum studied by 1H/13C magnetic resonance spectroscopy
Late effects of subarachnoid haemorrhage on the response of the primate cerebral circulation to drug-induced changes in arterial blood pressure
Brain damage after cardiopulmonary by-pass: correlations between neurophysiological and neuropathological findings
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Synthetic Genetic Array Analysis
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