Glucose control in the UKPDS: what did we learn?

Diabetic Medicine : a Journal of the British Diabetic Association
E A M Gale

Abstract

The UK Prospective Diabetes Study (UKPDS) set out to establish whether improved glucose control could alleviate the macrovascular and microvascular complications of diabetes and to compare the relative merits of diet, oral glucose-lowering agents or insulin in achieving this objective. The study broke many of the rules of trial design, not least by constant addition of further interventions and analyses, but this flexibility would, paradoxically, prove to be one of its greatest strengths. The UKPDS taught us that glucose control must be tackled aggressively in Type 2 diabetes. It taught us that treatment must be escalated in parallel with the evolution of pancreatic B-cell failure. It also taught us that glucose control is not enough: the central objective of therapy is to reduce vascular risk by any means available. This commentary looks back along the winding road that led to these conclusions.

References

Feb 26, 1977·Lancet·R R Holman, R C Turner
Dec 16, 1998·Diabetes Care·R C Turner
Oct 7, 2004·Perspectives in Biology and Medicine·Theodore B Schwartz, Curtis L Meinert
Jul 6, 2006·Diabetologia·E A M Gale
Sep 25, 2007·The New England Journal of Medicine·Rury R HolmanUNKNOWN 4-T Study Group

❮ Previous
Next ❯

Citations

Feb 17, 2009·Diabetes/metabolism Research and Reviews
May 1, 2010·Expert Review of Endocrinology & Metabolism·Robert G Moses
Oct 22, 2019·American Journal of Preventive Medicine·Megha K ShahMohammed K Ali

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.