Abstract
The gut hormone glucose-dependent insulinotropic polypeptide (GIP) causes postprandial insulin release and inhibits bone resorption assessed by carboxy-terminal collagen crosslinks (CTX). To study if GIP affects bone homeostasis biomarkers independently of insulin release and glycemic level. Randomized, double-blinded, crossover study with 5 study days. Ten male C-peptide-negative patients with type 1 diabetes. On 3 matched days with "low glycemia" (plasma glucose in the interval 3 to 7 mmol/L for 120 minutes), we administered intravenous (IV) GIP (4 pmol × kg-1 × min-1), glucagon-like peptide 1 (1 pmol × kg-1 × min-1), or placebo (saline), and on 2 matched days with "high glycemia" (plasma glucose 12 mmol/L for 90 minutes), we administered either GIP or saline. CTX, procollagen type 1 N-terminal propeptide (P1NP), and parathyroid hormone (PTH). During low glycemia: GIP progressively suppressed CTX from baseline by up to 59 ± 18% compared with 24 ± 10% during saline infusion (P < 0.0001). Absolute values of P1NP and PTH did not differ between days. During high glycemia: GIP suppressed CTX from baseline by up to 59 ± 19% compared with 7 ± 9% during saline infusion (P < 0.0001). P1NP did not differ between days. GIP suppressed PT...Continue Reading
References
Jul 1, 1996·Scandinavian Journal of Gastroenterology·C OrskovJ J Holst
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D M ThomasJ D Best
Sep 16, 1998·Bone·D M ThomasJ D Best
Mar 4, 2000·Endocrinology·R J BollagC M Isales
May 30, 2001·Molecular and Cellular Endocrinology·R J BollagC M Isales
Jan 17, 2002·Bone·N H BjarnasonC Christiansen
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Jackie A ClowesAubrey Blumsohn
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Jackie A ClowesAubrey Blumsohn
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jackie A ClowesRichard Eastell
Oct 13, 2005·Bone·Ding XieCarlos M Isales
Feb 14, 2006·Molecular Endocrinology·Katsushi TsukiyamaYutaka Seino
Sep 7, 2006·American Journal of Physiology. Endocrinology and Metabolism·Filip K KnopThure Krarup
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·Qing ZhongCarlos M Isales
Nov 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Katrine B HansenFilip K Knop
Dec 25, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S VasikaranUNKNOWN IOF-IFCC Bone Marker Standards Working Group
Aug 2, 2011·BMC Physiology·Elda L Pacheco-PantojaWilliam D Fraser
Feb 22, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xue MaXiaoxing Luo
Jul 16, 2013·Bone·Aleksandra MieczkowskaGuillaume Mabilleau
Jan 23, 2014·The Journal of Clinical Endocrinology and Metabolism·S S TorekovB L Langdahl
Jul 6, 2014·European Journal of Endocrinology·David P SonneFilip K Knop
Jul 24, 2014·Diabetes·Mikkel ChristensenFilip K Knop
Aug 22, 2014·The Journal of Clinical Endocrinology and Metabolism·Anne NissenBolette Hartmann
Jun 5, 2015·The Journal of Clinical Endocrinology and Metabolism·Eva W IepsenSigne S Torekov
Jun 7, 2015·Endocrine Connections·Kaisa K IvaskaHeikki A Koistinen
Oct 29, 2015·Climacteric : the Journal of the International Menopause Society·K HenriksenM A Karsdal
May 19, 2017·Frontiers in Endocrinology·Chenhe ZhaoXinhua Qu
Citations
Sep 21, 2018·Expert Review of Endocrinology & Metabolism·Rasmus Fuglsang-NielsenPeter Vestergaard
Oct 26, 2018·Histochemistry and Cell Biology·Linda J Fothergill, John B Furness
Jun 16, 2018·Endocrine Reviews·Megan E CapozziJonathan E Campbell
Feb 27, 2020·International Journal of Molecular Sciences·Yusaku MoriSho-Ichi Yamagishi
Jul 13, 2019·Basic & Clinical Pharmacology & Toxicology·Maria Buur Nordskov GabeMette Marie Rosenkilde
May 8, 2019·The Journal of Clinical Investigation·Soravis Osataphan, Mary Elizabeth Patti
Jun 7, 2020·Current Osteoporosis Reports·Vanessa D SherkViral N Shah
Jul 18, 2018·BMJ Open·Kerstin K AntonsenAnders Fink-Jensen
Feb 13, 2019·Journal of the Endocrine Society·Rachel L UsalaJoseph G Verbalis
Mar 14, 2019·Frontiers in Endocrinology·Sine Paasch SchiellerupMette Marie Rosenkilde
Nov 7, 2019·JBMR Plus·Anne NissenBolette Hartmann
Nov 6, 2018·Nutrients·Urszula RaznyMalgorzata Malczewska-Malec
Jul 28, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Qing ChenCaifeng Yan
Sep 10, 2020·Journal of the Endocrine Society·Mikkel B ChristensenFilip K Knop
Mar 9, 2019·The Journal of Clinical Endocrinology and Metabolism·Natasha Chidekel BergmannFilip Krag Knop
Nov 10, 2020·Current Osteoporosis Reports·Z Al-MashhadiJakob Starup-Linde
Dec 2, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·Ann BjørnshaveJakob Starup-Linde
Nov 13, 2019·Peptides·Signe StensenFilip Krag Knop
Aug 28, 2020·Bone·Julie AbildgaardBirgitte Lindegaard
Nov 26, 2019·Peptides·Sagar S VyavahareGuillaume Mabilleau
Mar 7, 2021·International Journal of Environmental Research and Public Health·Alessandra AmatoSara Baldassano
Aug 11, 2019·The Journal of Surgical Research·Vasiliki AntonopoulouKalliopi Kotsa
Apr 15, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kirsa Skov-JeppesenBolette Hartmann
Jun 1, 2021·Frontiers in Endocrinology·Yuhua WenLige Song
Jun 22, 2021·Bone·Kirsa Skov-JeppesenBolette Hartmann
Jul 26, 2021·Seminars in Cell & Developmental Biology·Morten Steen Hansen, Morten Frost
Sep 8, 2021·Diabetes, Obesity & Metabolism·Sebastian M N HeimburgerMikkel B Christensen