Glucose effects on memory: behavioral and pharmacological characteristics

Behavioral and Neural Biology
P E GoldJ L Hall

Abstract

Recent findings indicate that post-training glucose injections can modulate memory storage for inhibitory (passive) avoidance training. Experiment I extended these findings to determine whether glucose, like other memory modulating treatments, enhances memory storage when administered after training with low footshock and impairs memory storage after high footshock training. In Experiment I, male Sprague-Dawley rats were trained in a one-trial inhibitory avoidance task using either a brief footshock (0.5 mA, 0.7 s) or slightly more intense footshock kept on until escape (0.7 mA, mean escape latency = 3.4 s). Immediately after training, each rat received a subcutaneous injection of glucose (100 mg/kg). When tested for retention performance 24 h later, the glucose-injected animals exhibited enhanced retention performance for low footshock training and impaired retention for high footshock training. Experiment II determined whether pretreatment with adrenergic antagonists blocked the effects of glucose on memory. Pretreatment with the alpha- or beta-adrenergic receptor antagonists, phenoxybenzamine, or propranolol, respectively, had no effect on acquisition or retention in animals trained with the brief footshock and did not affec...Continue Reading

References

Jul 1, 1976·Journal of Neurochemistry·G E Gibson, J P Blass
Mar 25, 1975·Biochimica Et Biophysica Acta·W M Pardridge, W H Oldendorf
Jan 1, 1975·Psychiatria Clinica·S Hoyer, K Oesterreich
Sep 23, 1986·European Journal of Pharmacology·D B SternbergJ L McGaugh
May 1, 1986·Behavioral and Neural Biology·P E Gold
Sep 1, 1986·Behavioral and Neural Biology·J L Hall, P E Gold
Jun 1, 1974·Hormones and Behavior·L O Stratton, A J Kastin
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·W H Oldendorf
Jul 1, 1983·Behavioral and Neural Biology·P E Gold, S F Zornetzer
Dec 1, 1956·Pharmacological Reviews·S ELLIS

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Citations

Jan 1, 1988·Psychopharmacology·W S StoneP E Gold
Jan 1, 1991·Psychopharmacology·N P Azari
Jan 1, 1992·Psychopharmacology·D K Rush, K Streit
Sep 8, 2012·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Jan 1, 1987·Physiology & Behavior·L Gonder-FrederickP E Gold
Feb 1, 1992·Pharmacology, Biochemistry, and Behavior·J L HallP E Gold
May 1, 1990·Behavioral and Neural Biology·A C SantucciD C Riccio
Feb 1, 1996·Behavioural Brain Research·C Messier, M Gagnon
Sep 1, 1988·Peptides·J F FloodK Tatemoto
Jul 1, 1994·Neurobiology of Aging·J E MorleyF E Kaiser
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·G L Wenk, D S Olton
Mar 23, 2002·European Journal of Pharmacology·M Sibel GürünIsmail H Ulus
Mar 14, 2000·Physiology & Behavior·C R ParkS C Woods
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·J G Blanchard, P M Duncan
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·C R Park
Nov 1, 1994·Behavioral and Neural Biology·S R Kopf, C M Baratti
Mar 1, 1994·Behavioral and Neural Biology·W A RodriguezD D Phelps
Sep 1, 1986·Behavioral and Neural Biology·J L Hall, P E Gold
Aug 23, 2002·Behavioural Brain Research·Sandra I Sünram-LeaCatalina Perez
Mar 1, 1992·Journal of Clinical and Experimental Neuropsychology·S CraftL D Baker
May 17, 2007·Schizophrenia Bulletin·William S Stone, Larry J Seidman
Mar 7, 2009·Psychopharmacology·Inge E M de JongE Ronald de Kloet
Oct 1, 1996·Journal of Biosocial Science·D BentonR T Donohoe
May 23, 2012·Behavioural Brain Research·Paul E Gold, Sean M Wrenn
Jan 31, 2009·Neurobiology of Aging·Ken A MorrisPaul E Gold
Sep 1, 1988·Neurobiology of Aging·P E Gold, W S Stone
Sep 1, 1988·Neurobiology of Aging·W S Stone, P E Gold
Jul 16, 2010·Cardiovascular Psychiatry and Neurology·Johann SteinerBernhard Bogerts
Nov 16, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Sarah A Stern, Cristina M Alberini
Oct 7, 2004·Neurobiology of Learning and Memory·Paul E Gold
Apr 20, 2004·European Journal of Pharmacology·Claude Messier

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