Glucose homeostasis and gut-brain connection

Médecine sciences : M/S
Filipe De Vadder, Gilles Mithieux

Abstract

Since the XIX(th) century, the brain has been known for its role in regulating food intake (via the control of hunger sensation) and glucose homeostasis. Further interest has come from the discovery of gut hormones, which established a clear link between the gut and the brain in regulating glucose and energy homeostasis. The brain has two particular structures, the hypothalamus and the brainstem, which are sensitive to information coming either from peripheral organs or from the gut (via circulating hormones or nutrients) about the nutritional status of the organism. However, the efforts for a better understanding of these mechanisms have allowed to unveil a new gut-brain neural axis as a key regulator of the metabolic status of the organism. Certain nutrients control the hypothalamic homeostatic function via this axis. In this review, we describe how the gut is connected to the brain via different neural pathways, and how the interplay between these two organs drives the energy balance.

References

Sep 1, 1994·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·C Minassian, G Mithieux
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Hans-Rudolf Berthoud
Jun 12, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Bernard Thorens, Philip Just Larsen
Sep 15, 2004·The Journal of Biological Chemistry·Roger Gutiérrez-JuárezLuciano Rossetti
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Hans-Rudolf Berthoud
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Naoki UyamaHendrik Reynaert
Feb 5, 2005·Médecine sciences : M/S·Fabrizio Andreelli
Jul 31, 2007·Brain Research Reviews·Henri M Duvernoy, Pierre-Yves Risold
Sep 6, 2013·Médecine sciences : M/S·Arturo D Mancini, Vincent Poitout
Sep 10, 2013·The European Journal of Neuroscience·Fabien DelaereGilles Mithieux
Apr 2, 2014·Médecine sciences : M/S·Abdessamad El KaoutariBernard Henrissat
Jul 12, 2014·Médecine sciences : M/S·Eglantine Balland, Vincent Prévot

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Citations

May 12, 2015·Médecine sciences : M/S·Valentine S MoulléChristophe Magnan

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