PMID: 8955555Nov 1, 1996Paper

Glucose-induced [Ca2+]i oscillations in single human pancreatic islets

Cell Calcium
Franz Martin, B Soria

Abstract

Changes in cytosolic free calcium concentrations ([Ca2+]i) in response to stimulatory glucose concentrations were investigated in human pancreatic islets, using Fura-2 fluorescence imaging. Increasing glucose concentration from 3 to 11 mM caused a triphasic [Ca2+]i response in human islets: an initial decrease (phase 1), a rapid and transient increase (phase 2) and periodic oscillations with a frequency of 1 +/- 0.3 min-1 (phase 3). Raising the glucose concentration from 11 to 16.7 mM lowered the frequency of the glucose-induced [Ca2+]i oscillations to 0.15 +/- 0.2 min-1, without changes in their amplitude. Human islet [Ca2+]i response to stimulatory glucose concentrations is synchronous throughout the islet. Freshly isolated human islets responded to tolbutamide (50 microM) with a rise in [Ca2+]i. An increase in glucose concentration, from 3 to 16 mM, in the presence of 100 microM diazoxide, produced a decrease in [Ca2+]i. It is concluded that human islets respond to glucose with regular [Ca2+]i oscillations that are synchronous throughout the islet and whose duration is modulated by glucose.

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Citations

Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Daliang LiWen-hong Li
Mar 8, 2013·PLoS Computational Biology·Andraž StožerDean Korošak
Jan 7, 2014·PLoS Computational Biology·Michela RizMorten Gram Pedersen
Sep 23, 2014·Cell Calcium·Patrick GilonMagalie A Ravier
Oct 18, 2014·Cellular and Molecular Life Sciences : CMLS·Guy A Rutter, David J Hodson
Jan 5, 2002·Differentiation; Research in Biological Diversity·B Soria
Aug 20, 2003·European Journal of Clinical Investigation·J C HenquinP Gilon
Oct 25, 2012·Islets·Leonid E Fridlyand, Louis H Philipson
Nov 18, 2010·Biophysical Journal·Morten Gram Pedersen
Feb 12, 2009·Lab on a Chip·Javeed Shaikh MohammedDavid T Eddington
Feb 1, 2015·Molecular Aspects of Medicine·Leslie S SatinArthur S Sherman
Jan 30, 2002·Diabetes·Jean-Claude HenquinJean-Christophe Jonas
Jan 25, 2017·Diabetes, Obesity & Metabolism·Jean-Claude HenquinMyriam Nenquin
Apr 18, 2018·Journal of Molecular Endocrinology·Daniela Nasteska, David J Hodson
Oct 26, 2018·Nature Reviews. Endocrinology·James A FrankDavid J Hodson
Dec 12, 2013·American Journal of Physiology. Endocrinology and Metabolism·Kurt W ShortDavid W Piston
Nov 19, 2013·Molecular Endocrinology·Guy A Rutter, David J Hodson
May 6, 2004·American Journal of Physiology. Endocrinology and Metabolism·Milos Zarkovic, Jean-Claude Henquin
Aug 13, 2015·American Journal of Physiology. Endocrinology and Metabolism·Jean-Claude HenquinMyriam Nenquin
Sep 26, 2015·Physical Biology·Alessandro LoppiniMorten Gram Pedersen
Sep 11, 2019·Molecular Metabolism·Giselle Dominguez-GutierrezJesper Gromada
Feb 23, 2020·Seminars in Cell & Developmental Biology·Olof Idevall-Hagren, Anders Tengholm
Mar 10, 2010·Molecular and Cellular Endocrinology·William S CrimCraig S Nunemaker

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