PMID: 7011048Mar 1, 1981Paper

Glucose-induced electrical activity in the pancreatic beta-cell: effect of veratridine

The American Journal of Physiology
J T Tarvin, C S Pace

Abstract

Veratridine was used in the presence of glucose to assess the role of the Na pump in the regulation of glucose-induced burst activity. In the presence of 8.4 mM glucose, veratridine elicited a silent hyperpolarization, followed by burst activity. The magnitude of depolarization to plateau potential and the duration of the silent phase were increased. The addition of tetrodotoxin (TTX) restored the pattern of electrical activity to that observed in the absence of veratridine. Similar results were observed when veratridine was used in the presence of 16.7 mM glucose and tetraethylammonium (blocks voltage-dependent potassium permeability). TTX or ouabain blocked the effects of veratridine, and produced depolarization and continuous spike activity. Quinine (blocks Ca-dependent potassium permeability) elicited continuous spike activity in the presence of 16.7 mM glucose. The addition of veratridine induced only a transient return to burst activity, followed by a return to continuous spike activity. These results suggest that an electrogenic Na pump is an important factor in maintaining the transmembrane potential at an optimum level for operation of a voltage- and Ca-sensitive potassium permeability: changes in potassium permeabilit...Continue Reading

References

Jul 18, 1978·Pflügers Archiv : European journal of physiology·S KawazuW J Malaisse
Mar 1, 1975·The Journal of Physiology·E K Matthews, Y Sakamoto
Jan 1, 1974·Pflügers Archiv : European journal of physiology·H P Meissner, H Schmelz
Sep 1, 1970·The Journal of Physiology·P M Dean, E K Matthews

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Citations

Apr 1, 1988·Pflügers Archiv : European journal of physiology·T D Plant
Apr 1, 1988·Pflügers Archiv : European journal of physiology·L S Satin, D L Cook
Jan 1, 1983·Pflügers Archiv : European journal of physiology·H OberleithnerG Giebisch
Dec 8, 2017·Physiological Reviews·Patrik Rorsman, Frances M Ashcroft
Aug 1, 1987·Pflügers Archiv : European journal of physiology·N C SturgessM L Ashford

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