PMID: 7034727Aug 15, 1981Paper

Glucose-induced inactivation of mitochondrial enzymes in the yeast Saccharomyces cerevisiae

The Biochemical Journal
M Takeda

Abstract

1. Addition of glucose induced an inactivation of mitochondrial enzymes in the yeast Saccharomyces cerevisiae containing normal mitochondrial particles. 2. The glucose-induced inactivation of mitochondrial enzymes was inhibited by the presence of cycloheximide. 3. Pepstatin also inhibited the inactivation, but phenylmethanesulphonyl fluoride accelerated the inactivation. 4. The specific activities of fructose 1,6-bisphosphatase and cytoplasmic malate dehydrogenase were decreased on the exposure to glucose, as well as those of the mitochondrial enzymes. However, the glucose-induced inactivation of cytoplasmic enzymes was not inhibited by the presence of pepstatin. 5. The specific activities of hexokinase and phosphofructokinase, which are cytoplasmic enzymes were increased by the addition of glucose, and this effect was not affected by pepstatin. 6. Addition of glucose resulted in an increase in the synthesis of proteins of the mitochondria and the cytosol, and simultaneously in degradation of these mitochondrial and cytoplasmic proteins.

Citations

Aug 18, 2009·Biochimica Et Biophysica Acta·R Diaz-RuizM Rigoulet
May 11, 2011·Journal of Bioenergetics and Biomembranes·Sergio Guerrero-CastilloSalvador Uribe-Carvajal
Sep 21, 2019·Journal of Bioscience and Bioengineering·Makoto ImuraEiichiro Fukusaki
Oct 18, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yan XuAdalberto Pessoa
Aug 17, 2021·Molecular and Cellular Biology·Jaswinder Kaur, Kaustuv Datta

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