Glucose-induced paradoxical hyperkalemia in patients with suppression of the renin-aldosterone system: prevention by sodium depletion

Journal of Endocrinological Investigation
J P Radó


A paradoxical transitory elevation of serum potassium concentration after intravenous infusion of hypertonic glucose has been found in 6 renal and/or hypertensive patients with suppression of the renin-aldosterone system (RAS) while on high sodium intake. Sodium restriction induced a dramatic increase in plasma renin activity (PRA) and/or plasma aldosterone (PA) in every patient, a substantial fall in the elevated serum potassium levels in 4 out of the 6 patients and a marked increase in fractional potassium excretion. During sodium restriction the glucose-induced paradoxical transitory hyperkalemia was abolished. The study confirmed the important extrarenal influence of aldosterone in the maintenance of normal potassium level in the hyperosmolal extracellular fluid and showed that: i) high sodium intake may predispose to hazardous hyperkalemia after massive glucose loading in certain nondiabetic patients with liability to suppression of aldosterone; ii) sodium restriction abolishes the glucose-induced abnormal serum potassium response.


Sep 1, 1975·Biochemical Medicine·M Sparagana
May 1, 1977·Kidney International·R A DeFronzoZ S Agus
Sep 7, 1978·The New England Journal of Medicine·M CoxI Singer
Apr 1, 1976·Annals of Internal Medicine·S GoldfarbM Goldberg
Nov 1, 1975·The American Journal of Medicine·S GoldfarbM Goldberg
Dec 1, 1974·Metabolism: Clinical and Experimental·M S OhE S Whang
Jan 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T ItoR Horton
Jan 1, 1970·European Journal of Pharmacology·F MassaraM Rotunno

Related Concepts

Aldosterone, (+-)-Isomer
Blood Glucose
Diet, Salt-Free
Anhydrous Dextrose
Glucose Solution, Hypertonic
Renal Hypertension
Parenteral Infusion
Insulin B Chain

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