Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans

Genetics
Anastacia M GarciaPamela A Padilla

Abstract

Diet is a central environmental factor that contributes to the phenotype and physiology of individuals. At the root of many human health issues is the excess of calorie intake relative to calorie expenditure. For example, the increasing amount of dietary sugars in the human diet is contributing to the rise of obesity and type 2 diabetes. Individuals with obesity and type 2 diabetes have compromised oxygen delivery, and thus it is of interest to investigate the impact a high-sugar diet has on oxygen deprivation responses. By utilizing the Caenorhabditis elegans genetic model system, which is anoxia tolerant, we determined that a glucose-supplemented diet negatively impacts responses to anoxia and that the insulin-like signaling pathway, through fatty acid and ceramide synthesis, modulates anoxia survival. Additionally, a glucose-supplemented diet alters lipid localization and initiates a positive chemotaxis response. Use of RNA-sequencing analysis to compare gene expression responses in animals fed either a standard or glucose-supplemented diet revealed that glucose impacts the expression of genes involved with multiple cellular processes including lipid and carbohydrate metabolism, stress responses, cell division, and extracell...Continue Reading

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Dec 15, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Guoli ZhuJianhua Qin
Apr 7, 2017·American Journal of Physiology. Cell Physiology·Michael DavisJennifer A Schisa
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Feb 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Vaida JuozaityteRoger Pocock
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Mar 17, 2021·Scientific Reports·Samuel F KingsleyHeidi A Tissenbaum

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