PMID: 2496215Apr 1, 1989Paper

Glucose intolerance with low-, medium-, and high-carbohydrate formulas during nighttime enteral feedings in cystic fibrosis patients

Journal of Pediatric Gastroenterology and Nutrition
R E Kane, P Black

Abstract

Ten young adult cystic fibrosis (CF) patients over 16 years of age (average 21.4 years) began nighttime enteral feedings as a method of nutritional rehabilitation to regain and maintain body weight. Patients received nighttime feedings of 1,000 kcal/M2 of a low- (Pulmocare), medium- (Ensure Plus), or high-carbohydrate (Vivonex) formula for at least 2 nights each with pancreatic enzyme therapy. Five of ten young adult CF patients developed nocturnal hyperglycemia (serum glucose greater than 300 mg/dl) and glucosuria (1-3% glucose) with varying degrees of polyuria during enteral feedings. No patient developed ketonuria despite serum glucoses at times greater than 600 mg %. There was no difference between the hyperglycemic and normoglycemic groups in median age, percent of ideal body weight, NIH score, Brasfield scores, pulmonary function tests, or family history of diabetes. All normoglycemic and four of five hyperglycemic patients had normal fasting blood sugars. The percent hemoglobin A1c was greater in the glucose intolerant group than the normoglycemic patients (11.2 +/- 0.8% vs. 6.8 +/- 1.1%, mean +/- SE, p less than 0.005). Twelve to 15 units of NPH insulin prior to initiation of feedings provided adequate therapy in most h...Continue Reading

Citations

May 5, 2005·The Journal of Pediatrics·B C MarshallW J Morgan
Jul 28, 1999·Nutrition·D B Silk
Apr 5, 2003·Best Practice & Research. Clinical Gastroenterology·Reuben Jackson, Paul B Pencharz
Jun 19, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·H WhiteD G Peckham
Mar 18, 1999·Baillière's Clinical Gastroenterology·D Turck, L Michaud
Feb 11, 2005·Journal of Chemotherapy·D T BergstralhJ P Y Ting
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jamie M ErskineMarci Sontag
May 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·C MillaA Moran
Jun 6, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·A D R MackieF P Edenborough

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