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Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy

bioRxiv

Sep 4, 2014

Jessica B McGillenVíctor Manuel Pérez-García

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Abstract

A recent hypothesis has proposed a glucose-lactate metabolic symbiosis between adjacent hypoxic and oxygenated regions of a developing tumour, and proposed a treatment strategy to target this symbiosis. However, in vivo experimental support remains inconclusive. Here we develop a minima...read more

Mentioned in this Paper

Oxygen
Cellular Protein Metabolic Process
Tissue Oxygenation
Lactates
Lactic Acid Measurement
Cell Respiration
Metabolic Inhibition
Glucose Metabolism
Alveolar Ventilation Function
Research Study
5
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  • Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy

    bioRxiv

    Sep 4, 2014

    Jessica B McGillenVíctor Manuel Pérez-García

    PMID: 990008839

    DOI: 10.1101/008839

    Abstract

    A recent hypothesis has proposed a glucose-lactate metabolic symbiosis between adjacent hypoxic and oxygenated regions of a developing tumour, and proposed a treatment strategy to target this symbiosis. However, in vivo experimental support remains inconclusive. Here we develop a minima...read more

    Mentioned in this Paper

    Oxygen
    Cellular Protein Metabolic Process
    Tissue Oxygenation
    Lactates
    Lactic Acid Measurement
    5

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