PMID: 8957394Dec 1, 1996Paper

Glucose level and myocardial recovery after warm arrest

The Annals of Thoracic Surgery
X H NingS F Bolling

Abstract

During induced cold ischemia for cardiac operations, increasing glucose concentration is not thought to enhance myocardial protection and may detrimentally affect recovery. However, during "warm aerobic" arrest, increased glucose availability as substrate could enhance postischemic metabolic and functional recovery, as during and after ischemia, myocytes shift preference for substrate from fatty acids to glucose. Unfortunately, hyperglycemia may also increase patient susceptibility to neurologic injury. This experiment was designed to study the optimal dose of glucose and its effect on function during warm arrest. Isolated, retrograde-perfused rabbit hearts received multidose cardioplegia containing increasing concentrations of glucose, from 0 to 88 mmol/L, and underwent 120 minutes of "warm" 34 degrees C global ischemia. Osmolarities were adjusted equivalently. After 34 degrees C ischemia, hearts treated with 5 to 88 mmol/L glucose showed significantly better functional recovery than those treated with 0 to 1 mmol/L glucose. However, the addition of 22 mmol/L glucose demonstrated optimal recovery with no further incremental enhancement with more glucose. Additional hearts receiving 0 or 22 mmol/L glucose had high-energy phosph...Continue Reading

References

Oct 1, 1992·The Journal of Surgical Research·S F BollingX H Ning
Feb 1, 1991·The Annals of Thoracic Surgery·T A SalernoS V Lichtenstein
Apr 1, 1991·The Annals of Thoracic Surgery·J B SteinbergW M Daggett
Mar 10, 1990·European Journal of Biochemistry·R T MalletR Bünger
May 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·C K MezrowR B Griepp
Jan 1, 1993·Scandinavian Journal of Thoracic and Cardiovascular Surgery·L A BrodinG Ohqvist

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Citations

Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L GisselssonB K Siesjö
Apr 8, 1998·The American Journal of Physiology·X H NingM A Portman

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