Glucose metabolic and gluconeogenic pathways disturbance in the intrauterine growth restricted adult male rats

Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih
Xiao-mei LiuYan Lu

Abstract

To explore the molecular mechanism of type 2 diabetes in intrauterine growth restricted adult rats through determination of blood glucose and expression of gluconeogenic enzymes in liver. Male intrauterine growth restriction (IUGR) offspring induced by maternal protein-malnutrition and normal controls were studied. The body weights of offspring rats were weighted from birth to 12 weeks of age. Fasting plasma glucose and insulin levels were determined by glucose oxidase method and enzyme-linked immunosorbent assay (ELISA) respectively at 1 week, 8 weeks, and 12 weeks. Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase (G6Pase) mRNA and protein levels in liver were measured by real time RT-PCR and Western blot in newborn rats (Week 1) and adult rats (Week 12). Birth weights of IUGR rats were significantly lower than those of controls until 4 weeks later, when IUGR rats caught up to controls. Between 8 and 12 weeks, the growth of IUGR rats surpassed that of controls. No significant differences were observed in blood glucose and insulin levels at newborn rats between the two groups. However, by the end of 8 weeks IUGR rats develope...Continue Reading

References

Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·S SongJ Proietto
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li ChenB L G Nyomba
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Rodrigo A BazaesVerónica Mericq
Mar 26, 2004·Reviews in Endocrine & Metabolic Disorders·Peter StaehrHenning Beck-Nielsen
Jan 11, 2005·Journal of the American College of Nutrition·D J P Barker
Apr 7, 2007·Pediatric Research·Wayne S CutfieldIan M Morison
Apr 21, 2007·Journal of Internal Medicine·D J P Barker
Apr 21, 2007·Journal of Internal Medicine·M S Martin-Gronert, S E Ozanne
May 18, 2007·The New England Journal of Medicine·Petteri HoviEero Kajantie
Aug 10, 2007·The New England Journal of Medicine·Paolo ManzoniDaniele Farina
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak

❮ Previous
Next ❯

Citations

Nov 21, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lian-Hui ChenWei-Fen Zhu
Jun 23, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Nelma Cristina Silva PachecoLuiz Fabrizio Stoppiglia
May 16, 2020·International Journal of Endocrinology·Xiaomei LiuLinlin Gao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
F Assimacopoulos-Jeannet
Toxicology and Applied Pharmacology
J L Gingold, G DiPasquale
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
H WatanabeK Yabuta
© 2021 Meta ULC. All rights reserved