Glucose metabolism after pancreas transplantation: cyclosporine versus tacrolimus

Transplantation
Christoph D DieterleRüdiger Landgraf

Abstract

The results of the new immunosuppressants in simultaneous pancreas-kidney transplantation (SPK) concerning organ survival and rejection rates are excellent. Tacrolimus as well as cyclosporine are assumed to be diabetogenic; however, there are no comparative studies investigating their effects on glucose metabolism. One hundred thirty-six type 1 diabetic patients who had undergone successful SPK were investigated. Glucose and insulin levels during an oral glucose tolerance test as well as hemoglobin (Hb) A1c were analyzed. Investigations were performed early (3 months, n = 136) and late (3 years, n = 83) after transplantation. Graft recipients were grouped according to the first-line immunosuppression: group 1, cyclosporine; group 2, tacrolimus. There were no differences concerning age, gender, body mass index, and renal function between the groups. Early after transplantation, there was no difference between the groups concerning fasting glucose, HbA1c levels, basal and stimulated insulin secretion, and incidence of normal glucose tolerance. Late after transplantation, the incidence of a normal glucose tolerance tended to be lower (70% vs. 78%), whereas HbA1c (5.3% vs. 5.0%) and fasting glucose (81 vs. 78 mg/dL) levels tended t...Continue Reading

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Citations

Aug 2, 2006·Current Diabetes Reports·Emily C DyKristina I Rother
Jul 18, 2008·Current Diabetes Reports·Elizabeth Diakoff
Oct 25, 2006·Transplantation·Martin L MaiThomas Gonwa
Aug 2, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elvira O GosmanovaAidar R Gosmanov
Aug 15, 2014·Science Translational Medicine·Thusitha GajanayakeEsther Vögelin
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Savitha Subramanian, Dace L Trence
Nov 22, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Christoph D DieterleRüdiger Landgraf
Nov 1, 2006·Life Sciences·Mohammad A AjabnoorAdel Abdulrafee
Feb 24, 2007·Annales d'endocrinologie·M-C VantyghemC Noël

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