Glucose metabolism and colorectal carcinoma

Metabolism: Clinical and Experimental
C L LongJ Geiger

Abstract

We evaluated nine patients with colorectal cancer and six control patients in a postabsorptive state in an attempt to define the effect of cancer on glucose turnover, oxidation, recycling, and resting metabolic expenditures (RME). The glucose kinetics were determined using a double-labeled [U-14C] glucose and [6-3H] glucose, and energy expenditures were measured by indirect calorimetry. In addition, we also measured the same parameters in the cancer patient group on a total parenteral nutrition (TPN)-glucose system on the fourth day before and on the fifth day after removal of tumor. In the postabsorptive state, glucose turnover and oxidation rates were similar in the cancer and control group; however, the mean glucose pool size of the cancer group was 47% larger than the control group and was statistically significant (P = .05). Glucose recycling was also two times the control group and was statistically significant (P = .05). The recycling of glucose, both preoperatively and postoperatively, continued in the face of infused glucose; however, the rate was suppressed compared with the fasting cancer group. Postabsorptive RME of the cancer group did not differ from those predicted by the Harris-Benedict equation. Following a 4-d...Continue Reading

References

May 1, 1979·Cancer·A Theologides
Apr 1, 1979·Metabolism: Clinical and Experimental·C L LongJ R Broell
Nov 1, 1978·JPEN. Journal of Parenteral and Enteral Nutrition·C L LongW S Blakemore
Nov 1, 1979·JPEN. Journal of Parenteral and Enteral Nutrition·C L LongW S Blakemore
Oct 1, 1976·Physiology & Behavior·S D Morrison
Mar 1, 1976·International Journal of Radiation Oncology, Biology, Physics·C Waterhouse
Jul 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·C L Long
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·H W MerrickW S Blakemore
Nov 1, 1988·Metabolism: Clinical and Experimental·D W NixonJ M Daly
Jul 1, 1986·Archives of Surgery·D T DempseyG P Buzby
Nov 2, 1974·Lancet·S J O'KeefeW P James
Jan 1, 1974·Annals of the New York Academy of Sciences·J Gold
Jan 1, 1974·Annals of the New York Academy of Sciences·C Waterhouse
Jan 1, 1974·Cancer·C Waterhouse
Jul 1, 1971·Journal of Applied Physiology·C L LongJ W Geiger
Nov 1, 1983·Annals of Surgery·W A KokalI D Johnston
Sep 1, 1980·Metabolism: Clinical and Experimental·R R WolfeJ F Burke
Feb 1, 1983·Annals of Surgery·L S KnoxJ L Mullen
Aug 1, 1982·The British Journal of Surgery·J MacfieG L Hill
Jan 1, 1954·Advances in Cancer Research·L D FENNINGER, G B MIDER
Feb 1, 1956·The American Journal of Medicine·A R TEREPKA, C WATERHOUSE

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Citations

Apr 21, 1998·Surgery Today·Y Sakurai, S Klein
Aug 1, 1992·Journal of the American College of Nutrition·J A Tayek
Aug 4, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Dong-xing CaoZi-ang Yang
Dec 1, 1992·The British Journal of Surgery·J L McCallB R Parry
Aug 1, 1995·The American Journal of the Medical Sciences·J A TayekR T Chlebowski
Sep 1, 2010·Radiology and Oncology·Vaneja Velenik
Mar 19, 1999·Biochemical and Biophysical Research Communications·T YoshikawaS Satoh
Feb 13, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H P Sauerwein, J A Romijn

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