PMID: 7216234Dec 1, 1980Paper

Glucose metabolism and dehydrogenase activities in the cytosol and mitochondria of mouse LS cells in chemostat culture

In Vitro
R Sinclair


Energy metabolism has been examined in mouse LS cells growing under steady-state conditions in chemostat culture. The metabolic quotient of glucose oxidized (glucose consumed, but not fermented) remained constant, independent of growth rate between cell doubling times of 6 days and 1.2 days. Specific activities of cytochrome oxidase and malate dehydrogenase in the mitochondria remained constant at different growth rates, in accord with the constancy of the glucose oxidation rate. Cytosolic malate dehydrogenase activity was about fourfold greater than the mitochondrial isozyme. The steady-state rate of lactate production fluctuated because of technical limitations but correlated well with cytosolic lactate dehydrogenase activity.


Sep 1, 1976·Journal of Cellular Physiology·M Donnelly, I E Scheffler
Apr 1, 1978·Journal of Cellular Physiology·H R ZielkeM Cornblath
Sep 1, 1976·Experimental Cell Research·M Tovey, D Brouty-Boye
Apr 1, 1976·Experimental Cell Research·W C Dewey, M A Fuhr
Nov 14, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J P Griffiths, S J Pirt
Oct 17, 1968·European Journal of Biochemistry·D Dupourque, E Kun
Sep 1, 1953·The Biochemical Journal·R P HULLIN, R L NOBLE
Jul 1, 1956·Journal of General Microbiology·D HERBERTR C TELLING
Dec 1, 1959·Journal of General Microbiology·P D COOPERA M BURT
Dec 1, 1963·The Biochemical Journal·R L CROCKETT, I LESLIE
Aug 1, 1962·Experimental Cell Research·P A KITOSC WAYMOUTH

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