PMID: 4382012Oct 1, 1966

Glucose metabolism in the mucosa of the small intestine. Enzymes of the pentose phosphate pathway

The Biochemical Journal
L M Srivastava, G Hübscher

Abstract

1. The occurrence of five enzymes of the pentose phosphate pathway in cell-free preparations of the mucosa of rat small intestine is described. These enzymes were found to be localized mainly in the supernatant fraction (6240000g-min.). 2. The properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were studied with respect to K(m) values for substrates and NADP(+), pH optima and the effects of p-chloromercuribenzoate and palmitoyl-CoA. Higher total and specific activities of these two dehydrogenases were noted in the proximal half of the small intestine of the rat than in the distal half. 3. The specific activities of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the mucosa of the small intestine of the rat, cat, rabbit and guinea pig were compared. 4. In the rat the specific activities of ribose 5-phosphate isomerase, transketolase and transaldolase were higher in the supernatant fractions from the intestinal mucosa than in those from the liver. 5. The role of the pentose phosphate pathway is discussed in relation to the metabolism of hexose phosphates in the intestinal mucosa.

Citations

Aug 1, 1968·Experimental and Molecular Pathology·G RagnottiA Bernelli-Zazzera
Jan 1, 1968·Archiv für Mikrobiologie·L I Sly, H W Doelle
Oct 1, 1978·Journal of Learning Disabilities·L W Mayron
Dec 1, 1990·Diabetes/metabolism Reviews·K L RamaiyaK G Alberti
Sep 1, 1969·Archives of Environmental Health·O J Lucis, R Lucis
Jul 1, 1969·Zeitschrift für Ernährungswissenschaft·E Scharrer, H Zucker

Related Concepts

Chloromercuribenzoates
CoASH
Glucosephosphate Dehydrogenase
Structure of Intestinal Gland
Intestines, Small
Isomerase
Liver
2-Mercaptoethanol
NADP
Pentosephosphates

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