Glucose Metabolism in Turner Syndrome

Frontiers in Endocrinology
Lin SunXiaokun Gang

Abstract

Turner syndrome (TS) is one of the most common female chromosomal disorders. The condition is caused by complete or partial loss of a single X chromosome. Adult patients with TS have a high prevalence of diabetes mellitus (DM). Deranged glucose metabolism in this population seems to be genetically triggered. The traditional risk factors for DM in the general population may not play a major role in the pathogenesis of DM in patients with TS. This review focuses on the latest research studies pertaining to abnormalities of glucose metabolism in TS. We extensively review the available evidence pertaining to the influence of insulin secretion and sensitivity, obesity, autoimmunity, lifestyle, growth hormone, and sex hormone replacement therapy on the occurrence of DM in these patients.

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Citations

Aug 17, 2019·American Journal of Medical Genetics. Part a·Angela E LinClaus H Gravholt
Jun 20, 2019·Nature Reviews. Endocrinology·Claus H GravholtNiels H Andersen
Aug 28, 2020·Frontiers in Endocrinology·Francisco Álvarez-NavaJéssica Guarderas
Aug 1, 2021·Hormone Molecular Biology and Clinical Investigation·Francisco Álvarez-NavaMarcia Racines-Orbe
Jun 1, 2020·Current Pharmaceutical Design·Eirini KostopoulouDimitrios G Goulis

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Methods Mentioned

BETA
hormone replacement therapy

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