Glucose metabolism, lipid metabolism, and cardiovascular risk factors in adult Turner's syndrome. The impact of sex hormone replacement

Diabetes Care
Claus Højbjerg GravholtJens Sandahl Christiansen

Abstract

To examine glucose metabolism, blood pressure, physical fitness, and lipid metabolism in adult untreated women with Turner's syndrome compared with a group of normal women and to examine the effects of female sex hormone substitution on these factors. A total of 26 patients with Turner's syndrome were examined before and during sex hormone replacement with 17 beta-estradiol and norethisterone, and an age-matched control group (n = 24) was examined once. A frequently sampled intravenous glucose tolerance test was applied with minimal model assessment. We also performed an oral glucose tolerance test, measurement of 24-h ambulatory blood pressure, and assessment of physical fitness and lipid metabolism. Insulin sensitivity (SI) and glucose effectiveness (SG) were similar in Turner's syndrome patients and control subjects, whereas the acute insulin response (P = 0.03) was lower in Turner's syndrome patients, and no change was seen during sex hormone treatment. Abnormal glucose tolerance was found in 50% of Turner's syndrome patients before and 78% during treatment with sex hormones. Fat-free mass (FFM; P = 0.0005) and physical fitness (P = 0.002) were lower in Turner's syndrome subjects compared with control subjects. During treat...Continue Reading

Citations

Nov 29, 2005·Reviews in Endocrine & Metabolic Disorders·Carolyn A Bondy
Sep 13, 2006·Current Hypertension Reports·Muhammad S Ashraf, Wanpen Vongpatanasin
Dec 8, 2011·Endocrine·Christian TrolleClaus H Gravholt
Aug 25, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Claus H Gravholt
Oct 23, 2013·Nature Reviews. Endocrinology·Sara Della TorreAdriana Maggi
Jun 18, 2011·Current Opinion in Obstetrics & Gynecology·Amanda N Kallen, Lubna Pal
Feb 7, 2008·Hormone Research·Sabine M P F de Muinck Keizer-Schrama
Mar 17, 2011·BMC Endocrine Disorders·Britta E HjerrildClaus H Gravholt
Mar 13, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Britta E HjerrildClaus H Gravholt
Mar 20, 2008·The Journal of Clinical Endocrinology and Metabolism·Nicole WootenCarolyn A Bondy
Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·Vladimir K BakalovCarolyn A Bondy
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Claus Højbjerg Gravholt
Dec 1, 2008·Journal of Clinical Research in Pediatric Endocrinology·Özgür PirgonRıdvan Güçlü
Aug 11, 2001·Lancet·M B Ranke, P Saenger
Oct 5, 2006·Menopause : the Journal of the North American Menopause Society·Emily C CorriganCarolyn A Bondy
Mar 2, 2006·Journal of Hypertension·Claus Højbjerg GravholtJens Sandahl Christiansen
Aug 7, 2004·Hormone Research·F VerlindeUNKNOWN Belgian Study Group of Paediatric Endocrinology
Dec 1, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Solange Travassos de Figueiredo AlvesMarília Martins Guimarães
Feb 5, 2002·Expert Opinion on Pharmacotherapy·C H Gravholt
Jan 30, 2003·Medical and Pediatric Oncology·Karsten NysomChristian Mølgaard
Dec 18, 2015·BBA Clinical·Meenal Mavinkurve, Clodagh S O'Gorman
Nov 17, 2015·Endocrinology and Metabolism Clinics of North America·Lisal J Folsom, John S Fuqua
Apr 1, 2008·Congenital Heart Disease·Carolyn A Bondy
Apr 6, 2006·Clinical Endocrinology·Nehama Zuckerman-LevinZe'ev Hochberg
Oct 31, 2012·Clinical Endocrinology·Clodagh S O'GormanJill K Hamilton
Nov 24, 2012·Clinical Endocrinology·Emma J TurtleDavid J Webb
Jul 5, 2012·Echocardiography·Kristian Havmand MortensenNiels Holmark Andersen
Jun 1, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Marsha L Davenport
Jun 1, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michelle P Warren, Abigail Chua
Jun 18, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Gerard S Conway
Nov 11, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Karen R Rubin
Sep 28, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tracy L SetjiAnn J Brown
Feb 24, 2015·Case Reports in Medicine·JayaKrishna ChintanaboinaThomas R Riley
Oct 14, 2008·Archives of Cardiovascular Diseases·Yves DulacPhilippe Acar
Mar 23, 2011·The American Journal of Cardiology·Giancarlo TancrediBruno Marino
May 21, 2016·Frontiers in Endocrinology·Maria Felicia FaienzaGiacomina Brunetti
Nov 16, 2005·Hormone Research·Claus Højbjerg Gravholt
Jan 6, 2012·Arquivos brasileiros de endocrinologia e metabologia·Paulo Ferrez Collett-SolbergMarilia Martins Guimarães
Apr 24, 2010·Arquivos brasileiros de endocrinologia e metabologia·Alexis D GuedesIeda T N Verreschi

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Journal of Clinical Epidemiology
Claus Højbjerg GravholtJ Hansen
Clinical Endocrinology
N C NathwaniP C Hindmarsh
The Journal of Clinical Endocrinology and Metabolism
Vladimir BakalovCarolyn A Bondy
The Journal of Clinical Endocrinology and Metabolism
S CaprioW V Tamborlane
© 2022 Meta ULC. All rights reserved