PMID: 11921430Mar 29, 2002Paper

Glucose monitoring by reverse iontophoresis

Diabetes/metabolism Research and Reviews
R O PottsMichael J Tierney

Abstract

Glucose can be extracted through intact skin by electro-osmotic flow (a process called 'reverse iontophoresis') upon the application of a low-level electrical current. Recently we have combined iontophoretic extraction with an in situ glucose sensor in a device called the GlucoWatch biographer. Clinical results with this device show close tracking of blood glucose over a range of 2.2 to 22.2 mmol/l for up to 12 h using a single blood glucose value as calibration. The biographer readings lag behind blood glucose values by an average of 18 min. An analysis of data from 92 diabetic subjects in a controlled clinical setting shows a linear relationship (r=0.88) between GlucoWatch biographer readings and blood glucose. The mean absolute relative difference between the two measurements was 15.6% and more than 96% of the data fell in the (A+B) regions of the Clarke error grid. Similar results have been obtained from subjects using the GlucoWatch biographer in an uncontrolled home environment. The automatic, frequent, and non-invasive measurements obtained with the GlucoWatch biographer provide substantially more information about glucose levels than do the current fingerstick methods. This information can be used for improved decisions...Continue Reading

References

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Citations

Oct 25, 2002·Diabetes/metabolism Research and Reviews
Apr 20, 2004·BMC Medicine·Terry O HerndonJames C Weaver
Jan 5, 2005·Diabetes Technology & Therapeutics·Eva TsalikianUNKNOWN Diabetes Research in Children Network (DirecNet) Study Group
Nov 23, 2006·Current Eye Research·Jennifer D LaneCarol Morris
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May 8, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Raeann Gifford
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