Glucose regulates the histone acetylation of gene promoters in decidualizing stromal cells

Reproduction : the Official Journal of the Society for the Study of Fertility
Kosuke JozakiNorihiro Sugino

Abstract

Decidualization stimuli activate the insulin signaling pathway and increase the glucose uptake in human endometrial stromal cells (ESCs). The inductions of prolactin (PRL) and IGF-binding protein-1 (IGFBP1), specific markers of decidualization, were inhibited by incubating ESCs under low glucose concentrations. These results suggested that decidualization stimuli activate the insulin signaling pathway, which contributes to decidualization through the increase of glucose uptake. Here, we investigated the mechanisms by which glucose regulates decidualization. ESCs were incubated with cAMP to induce decidualization. We examined whether low glucose affects the expression levels of transcription factors that induce decidualization. Forkhead box O1 (FOXO1) expression was significantly suppressed under low glucose conditions. Knockdown of FOXO1 by siRNA inhibited the expression levels of PRL and IGFBP1 during decidualization. Taken together, our results showed that low glucose inhibits decidualization by decreasing FOXO1 expression. We also examined the levels of histone H3K27 acetylation (H3K27ac), which is related to active transcription, of the promoter regions of FOXO1, PRL and IGFBP1 by ChIP assay. The H3K27ac levels of these pro...Continue Reading

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Citations

Feb 27, 2020·The Journal of Biological Chemistry·Isao TamuraNorihiro Sugino
Dec 22, 2020·Frontiers in Physiology·Tamas Zakar, Jonathan W Paul
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Jiaxing LiYun Sun
Jun 13, 2021·Reproductive Biology and Endocrinology : RB&E·Shijian LvCong Zhang

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