PMID: 6989790Jan 1, 1980Paper

Glucose repression and autolysis of Saccharomyces cerevisiae cells: alterations in the cytochemical localization of acid phosphatase

The Histochemical Journal
E I RaininaV N Luzikov

Abstract

Alterations in the localization of acid phosphatase in Saccharomyces cerevisiae during glucose repression and during autolysis have been studied. Cell morphology becomes distinctly changed after only 2 h in the presence of high glucose concentration while after 3 h of glucose repression the majority of the mitochondrial structures resemble promitochondria. Yeast cells repressed for 6 h contain almost completely degraded mitochondrial structures and numerous lipid droplets in the central vacuole and cytoplasm. Destruction of mitochondria is accompanied by the accumulation of acid phosphatase in these organelles and in the cytoplasm, whereas its activity in the central vacuole is lowered, most probably because of the leakage of the enzyme into the cytoplasm. No preferential breakdown of mitochondria is observed during autolysis. On the contrary, mitochondria are apparently the last to be degraded. Digestion of cytoplasmic regions and membranous elements occurs intravacuolarly after sequestration by protrusions of the central vacuole which are formed at the initial stages of autolysis. Acid phosphatase is not released from the central vacuole, suggesting indirectly that vacuole enzymes do not migrate into the cytoplasm during auto...Continue Reading

References

Mar 28, 1975·Biochimica Et Biophysica Acta·T Saheki, H Holzer
Sep 1, 1975·Journal of Bacteriology·H J van RijnP Boer
Apr 1, 1972·Journal of Ultrastructure Research·D F Travis, A Travis
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Feb 6, 1970·Biochemical and Biophysical Research Communications·W K NealC A Price
Jan 1, 1968·European Journal of Biochemistry·W DuntzeH Holzer
Jan 1, 1969·Biochemistry·H Plattner, G Schatz

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