PMID: 3902101Jan 1, 1985

Glucose response to bursting-spiking pancreatic beta-cells by a barrier kinetic model

Biological cybernetics
T R Chay


A mathematical model of the pancreatic beta-cell electrical activity was developed using a barrier kinetic model. Our model incorporates the glucose sensitive channel which is known to conduct K+ in the absence of glucose. The model also incorporates Cai sensitive K+ channels which are inhibited by intracellular H+ ions. It is described by three non-linear simultaneous differential equations. Numerical integration of these equations allowed us to examine the effect of glucose and of external Ca2+ ions on the electrical and cellular activity of the beta-cell. Our results show that the contribution of glucose-sensitive channel activity, if not completely inhibited, plays a very important role in determining the bursting periodicity. Our results also shows that even a small decrease in pHi is sufficient to change a bursting beta-cell to a spiking one. The voltage dependence of calcium sensitive K+ channels, however, affects little to the bursting mode of the electrical activity. Our simulation supports an incomplete selectivity of the voltage dependent calcium channel for calcium ions with low external [Ca2+]. It also supports the role of [Ca]i as an inhibitor of this channel when [Ca]i becomes unusually high.


Sep 7, 1979·Journal of Theoretical Biology·T R Chay
Sep 1, 1979·The American Journal of Physiology·B Ribalet, P M Beigelman
Mar 1, 1985·Biophysical Journal·T R Chay, J Rinzel
Jan 1, 1972·Endocrinology·B HellmanI B Täljedal
Jan 1, 1974·Pflügers Archiv : European journal of physiology·H P Meissner, H Schmelz
Sep 1, 1970·The Journal of Physiology·P M Dean, E K Matthews
Jan 1, 1984·Biological cybernetics·T R Chay
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Aug 1, 1983·European Journal of Biochemistry·P Bernardi, G F Azzone
Apr 1, 1980·Physiological Reviews·C J Hedeskov
May 1, 1983·Biophysical Journal·T R Chay, J Keizer
Jul 1, 1983·Biophysical Chemistry·Y S LeeT Ree
Feb 23, 1984·Nature·O H Petersen, Y Maruyama
Mar 1, 1983·The American Journal of Physiology·G T Eddlestone, P M Beigelman
Sep 1, 1980·The American Journal of Physiology·B Ribalet, P M Beigelman
Dec 15, 1980·The Journal of Membrane Biology·E HeinzB Pfeiffer
Apr 1, 1980·Biophysical Journal·T R Chay
Sep 20, 1943·The Journal of General Physiology·D E Goldman

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