Glucose sensing in human epidermis using mid-infrared photoacoustic detection.

Biomedical Optics Express
Jonas KottmannM W Sigrist

Abstract

No reliable non-invasive glucose monitoring devices are currently available. We implemented a mid-infrared (MIR) photoacoustic (PA) setup to track glucose in vitro in deep epidermal layers, which represents a significant step towards non-invasive in vivo glucose measurements using MIR light. An external-cavity quantum-cascade laser (1010-1095 cm(-1)) and a PA cell of only 78 mm(3) volume were employed to monitor glucose in epidermal skin. Skin samples are characterized by a high water content. Such samples investigated with an open-ended PA cell lead to varying conditions in the PA chamber (i.e., change of light absorption or relative humidity) and cause unstable signals. To circumvent variations in relative humidity and possible water condensation, the PA chamber was constantly ventilated by a 10 sccm N(2) flow. By bringing the epidermal skin samples in contact with aqueous glucose solutions with different concentrations (i.e., 0.1-10 g/dl), the glucose concentration in the skin sample was varied through passive diffusion. The achieved detection limit for glucose in epidermal skin is 100 mg/dl (SNR=1). Although this lies within the human physiological range (30-500 mg/dl) further improvements are necessary to non-invasively mo...Continue Reading

References

May 1, 1993·Medical & Biological Engineering & Computing·G B Christison, H A MacKenzie
Aug 12, 2000·Journal of Biomedical Optics·R J McNichols, G L Coté
Nov 28, 2002·Diabetes Care·Carl D MalchoffJanusz M Buchert
Jul 5, 2003·Biological & Pharmaceutical Bulletin·Yaw-Bin HuangYi-Hung Tsai
Jul 23, 2003·Diabetes Technology & Therapeutics·Suzanne GebhartMadeleine Vanstory
Jul 26, 2003·The Journal of Investigative Dermatology·Kathi C Madison
Oct 18, 2005·The American Journal of Medicine·Eric Renard
Oct 19, 2005·Journal of Biomedical Optics·James L LambertMark Borchert
Oct 19, 2005·Journal of Biomedical Optics·Annika M K EnejderMichael S Feld
Jan 5, 2006·Applied Spectroscopy·Jonathon T OlesbergJoachim Wagner
Jun 28, 2006·Diabetes Technology & Therapeutics·Wayne MarchShobit Rastogi
Oct 19, 2007·Medical Engineering & Physics·Carlos Eduardo Ferrante do Amaral, Benhard Wolf
Aug 22, 2008·Diabetes Technology & Therapeutics·W GroenendaalP A J Hilbers
Mar 10, 2010·Journal of Biomedical Optics·Bilal H Malik, Gerard L Coté
Sep 8, 2011·The Review of Scientific Instruments·J KottmannM W Sigrist

❮ Previous
Next ❯

Citations

Dec 10, 2013·Cell and Tissue Research·Fabio Quondamatteo
Aug 29, 2014·BioMed Research International·Anwarul HasanAyad A Jaffa
Jun 14, 2013·Biomedical Optics Express·Wanjie ZhangKexin Xu
Nov 27, 2014·Biomedical Optics Express·Ningning SongAnabela Da Silva
Aug 11, 2015·Journal of Advanced Research·Markus W Sigrist
Dec 6, 2016·The Analyst·Arthur SchönhalsWolfgang Petrich
Sep 23, 2014·Applied Spectroscopy·Lizhu ZhangBenli Yu
Jan 4, 2013·Sensors·Jonas KottmannMarkus W Sigrist
Aug 18, 2017·Chemical Society Reviews·Andreas SchwaighoferBernhard Lendl
Oct 4, 2012·Applied Spectroscopy·Rohit Bhargava
Mar 14, 2020·The Analyst·Shazzad RasselDayan Ban
Nov 18, 2018·The Analyst·Katharina IsenseeWolfgang Petrich
Feb 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jaya PrakashVasilis Ntziachristos
Apr 19, 2016·Journal of Biomedical Optics·Yong ZhouLihong V Wang
Apr 6, 2018·Frontiers in Endocrinology·Ara GhazaryanVasilis Ntziachristos
Mar 15, 2019·Sensors·Ruochong ZhangYuanjin Zheng
Oct 10, 2020·The Analyst·Ruochong ZhangYuanjin Zheng

❮ Previous
Next ❯

Methods Mentioned

BETA
chip
circumcisions

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.