Glucose-sensitive silicone hydrogel contact lens toward tear glucose monitoring

Journal of Biomedical Optics
Ramachandram BaduguJoseph R Lakowicz

Abstract

Accurate and reliable monitoring of blood glucose is needed for the treatment of diabetes, which has many challenges, including lack of patient compliance. Measuring tear glucose is an alternative to traditional finger-stick tests used to track blood sugar levels, but glucose sensing using tears has yet to be achieved. We report a methodology for possible tear glucose monitoring using glucose-sensitive silicone hydrogel (SiHG) contact lenses, the primary type of lenses available in today's market. Initially, we assessed the interpenetrating polymer network, with nearly pure silicone and water regions, existing in the SiHGs using a polarity-sensitive probe Prodan. We then synthesized a glucose-sensitive fluorophore Quin-C18 with a hydrophobic side chain for localization of probe at the interfacial region. Using our glucose-sensing contact lens, we were able to measure varying concentrations of glucose in an in-vitro system. The Quin-C18 strongly bound to the lenses with insignificant leaching even after multiple rinses. The lenses displayed a similar response to glucose after three months of storage in water. This study demonstrates that it may be possible to develop a contact lens for continuous glucose monitoring in the near t...Continue Reading

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Citations

Feb 25, 2020·Macromolecular Rapid Communications·Danielle BruenLarisa Florea
Feb 9, 2021·Sensors and Actuators. B, Chemical·Ramachandram BaduguJoseph R Lakowicz
Jan 18, 2021·Drug Delivery and Translational Research·Onyinye J UwaezuokeYahya E Choonara
Feb 4, 2021·Microsystems & Nanoengineering·An'an ShengHuanyu Cheng
Dec 10, 2020·Sensors·Liu TangJen-Tsai Liu
Feb 20, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pinal ChaudhariShaila A Lewis
May 17, 2019·Biosensors & Bioelectronics·Juliane R SempionattoJoseph Wang
Mar 7, 2021·Biosensors·José Luis Cano PerezRoberto Rojas Laguna
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Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Lyndon JonesMark Willcox
Jun 22, 2021·Nanoscale·Linling XuAli Zavabeti
Jul 25, 2021·Sensors·Maru AndoHiroaki Onoe
Oct 19, 2019·Analytical Chemistry·Juliane R SempionattoJoseph Wang
Oct 1, 2021·The Analyst·Yuqi ShiAli K Yetisen

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