Glucose-stimulated acidogenesis by Streptomyces peucetius

Canadian Journal of Microbiology
M L Dekleva, W R Strohl

Abstract

Cultures of Streptomyces peucetius often were observed to divert spontaneously from the production of anthracycline antibiotics to the excretion of acidic metabolites, whether grown in a defined medium or a nutrient-rich medium. The predominant excreted acidic metabolites were determined by high-performance liquid chromatography to be pyruvate and 2-oxoglutarate. The acidification occurred at high frequencies when glucose was the primary carbon source in a defined medium, at intermediate frequencies when fructose was the primary carbon source, and did not occur when either maltose, starch, or dextrin were used as primary carbon sources.

Citations

Aug 30, 2008·Science in China. Series C, Life Sciences·H Xia, Y Wang
Sep 12, 2002·Journal of Microbiological Methods·Merja SuutariA Nevalainen
Oct 10, 2015·Microbial Cell Factories·Howbeer MuhamadaliRoyston Goodacre
Jun 18, 2005·Letters in Applied Microbiology·M KontroA Nevalainen
Jan 27, 2015·Applied Biochemistry and Biotechnology·Alba RomeroSergio Sanchez

Related Concepts

Fermentation
Anhydrous Dextrose
Hydrogen-Ion Concentration
Streptomyces

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