PMID: 9530133Apr 8, 1998Paper

Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes

The American Journal of Physiology
F Bradley Hillgartner, T Charron

Abstract

Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high during feeding a high-carbohydrate, low-fat diet. The role of glucose in the nutritional control of FAS and ME was investigated by determining the effects of this metabolic fuel on expression of FAS and ME in primary cultures of chick embryo hepatocytes. In the presence of triiodothyronine, glucose (25 mM) stimulated an increase in the activity and mRNA abundance of FAS and ME. These effects required the phosphorylation of glucose to glucose 6-phosphate but not further metabolism downstream of the aldolase step of the glycolytic pathway. Xylitol mimicked the effects of glucose on FAS and ME expression, suggesting that an intermediate of the pentose phosphate pathway may be involved in mediating this response. The effects of glucose on the mRNA abundance of FAS and ME were accompanied by similar changes in transcription of FAS and ME. These data support the hypothesis that glucose plays a role in mediating the effects of nutritional manipulation on transcription of FAS and ME in liver.

References

May 1, 1977·Analytical Biochemistry·J J Sedmak, S E Grossberg
Feb 1, 1986·Analytical Biochemistry·R M Amasino
Jan 1, 1986·The International Journal of Biochemistry·A B JenkinsE W Kraegen
Sep 15, 1986·European Journal of Biochemistry·S Giffhorn-Katz, N R Katz
Sep 30, 1986·Biochemical and Biophysical Research Communications·H KlandorfJ Brown
Jan 1, 1986·Annals of the New York Academy of Sciences·A G GoodridgeM J Goldman
Oct 1, 1972·Archives of Biochemistry and Biophysics·M C CraigJ W Porter
Jul 1, 1968·Comparative Biochemistry and Physiology·E K O'Hea, G A Leveille
Jan 1, 1983·Annual Review of Biochemistry·S J WakilV C Joshi
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Dec 1, 1984·The Biochemical Journal·J C StanleyE A Newsholme
Jan 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J GirardP Ferré
Apr 12, 1996·The Journal of Biological Chemistry·Y Q Liu, K Uyeda
Jan 1, 1996·Progress in Nucleic Acid Research and Molecular Biology·A G GoodridgeC Roncero
Mar 1, 1997·Progress in Lipid Research·C F Semenkovich
Nov 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·E M WISE, E G BALL
Jun 1, 1973·The Biochemical Journal·H F Woods, H A Krebs

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