Glucose tolerance and insulin action in healthy centenarians

The American Journal of Physiology
G PaolissoF D'Onofrio

Abstract

Advancing age has been found to be associated with a decline in insulin action. Nevertheless, no study has been conducted in healthy centenarians. Our study investigates glucose tolerance and insulin action in centenarians. Fifty-two subjects were enrolled. The subjects were divided in three groups as follows: 1) adults (< 50 yr; n = 20);2) aged subjects (> 75 yr; n = 22); and 3) centenarians (> 100 yr; n = 14). Body composition was studied by bioimpedance analysis. In all subjects, an oral glucose tolerance test and euglycemic glucose clamp were performed. Centenarians have a lower fat-free mass (FFM) than aged subjects and adults, whereas fasting plasma glucose, triglycerides, free fatty acids, urea, and creatinine were not different in the groups studies. Centenarians had a 2-h plasma glucose concentration (6.0 +/- 0.2 mmol/l) that was lower than that in aged subjects (6.6 +/- 0.5 mmol/l, P < 0.05) but not different from adults [6.4 +/- 0.4 mmol/l, P = not significant (NS)]. During the clamp, plasma glucose and insulin concentrations were similar in the three groups. In these conditions, centenarians had a whole body glucose disposal (34.1 +/- 0.6 mumol.kg FFM-1.min 1) that was greater than that in aged subjects (23.3 +/- 0....Continue Reading

Citations

Mar 16, 2007·The Journal of Clinical Endocrinology and Metabolism·Rossana M C PereiraRoberto Salvatori
Apr 17, 2013·Physiological Reviews·Andrzej BartkeValter Longo
Mar 30, 2019·Frontiers in Endocrinology·Yasumichi AraiNobuyoshi Hirose
Jul 22, 1998·Journal of the American Geriatrics Society·G PaolissoM Varricchio
Oct 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michelangela BarbieriGiuseppe Paolisso
Dec 21, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Malgorzata S Martin-GronertSusan E Ozanne
Aug 6, 2010·Endocrine Journal·Bianca HemmeryckxH Roger Lijnen
Nov 19, 2011·American Journal of Physiology. Endocrinology and Metabolism·C A WijsmanD van Heemst
Jun 13, 2009·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Yasumichi Arai, Nobuyoshi Hirose
May 10, 2011·Journal of Atherosclerosis and Thrombosis·Yasumichi AraiNobuyoshi Hirose
Apr 12, 2000·European Journal of Clinical Investigation·G PaolissoM Varricchio
Jul 13, 2000·Free Radical Biology & Medicine·P MecocciU Senin
Aug 8, 2021·International Journal of Molecular Sciences·Joseph A M J L Janssen

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