Glucose tolerance in the proximal versus the distal small bowel in Wistar rats.

Obesity Surgery
Marcus Vinicius Dantas de Campos MartinsCarolina Barreira Albano Aratanha

Abstract

Type 2 diabetes is an epidemic and insulin resistance is the central etiology of this disease. Obesity increases insulin resistance and glucose intolerance and also exacerbates metabolic abnormalities present in type 2 diabetes. Bariatric surgery is the most effective treatment for severe obesity. Most reported series show that return to euglycemia and normal insulin levels occur days after gastric bypass and biliopancreatic diversion, long before major weight loss has taken place. The mechanisms underlying this dramatic reversal of type 2 diabetes following these bariatric procedures are not well understood. Twelve Wistar rats were fed with a palatable hyperlipidic diet for 12 weeks. Body weight, glucose, and intraperitoneal glucose tolerance test were measured regularly. On day 91, they were randomized in two groups (hindgut and controls) and operated. Twenty-one days later, the tests were done again and the hindgut group re-operated. A duodenal exclusion was done. The results of an intraperitoneal glucose tolerance test were compared after the procedures. Body weight increased regularly in all the rats. Some rats developed hyperglycemia 28 days after beginning hyperlipidic diet, but these levels returned to baseline on days ...Continue Reading

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Citations

Mar 7, 2009·Obesity Surgery·Sheetal Bharat MistrySubhash Kini
Nov 18, 2010·Obesity Surgery·Raghavendra S Rao, Subhash Kini
Jan 7, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H AshrafianT Athanasiou
Oct 1, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H AshrafianS R Bloom

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