Glucose Tolerance is Linked to Postprandial Fuel Use Independent of Exercise Dose

Medicine and Science in Sports and Exercise
Nicole M GilbertsonSteven K Malin

Abstract

The optimal short-term exercise dose to improve glucose tolerance in relation to metabolic flexibility and/or insulin resistance is unknown. Therefore, we tested if short-term, work-matched continuous (CONT) versus interval (INT) exercise training improves glucose tolerance in part by reducing insulin resistance and increasing metabolic flexibility independent of clinically meaningful fat loss in adults with prediabetes. Subjects (age = 60.9 ± 1.4 yr, body mass index = 33.5 ± 1.1 kg·m) were screened for prediabetes using the American Diabetes Association criteria (75 g oral glucose tolerance test [OGTT] and/or HbA1c) and were randomized to 60 min·d of supervised CONT (n = 17, 70% HRpeak) or work-matched INT (n = 14; 90% HRpeak for 3 min and 50% HRpeak for 3 min) exercise for 12 bouts. Fitness (V˙O2peak) and body composition were assessed pre- and postintervention. A 180-min 75-g OGTT was performed, and glucose, insulin, and free fatty acids were collected to calculate glucose tolerance (tAUC180min) and whole-body as well as adipose tissue insulin resistance pre- and postintervention. RER (indirect calorimetry) was also measured at 0, 60, 120, and 180 min of the OGTT to assess fasting and postprandial metabolic flexibility. CONT...Continue Reading

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Citations

Jan 11, 2019·Journal of Applied Physiology·Emily M HeistonSteven K Malin
Aug 10, 2019·Oxidative Medicine and Cellular Longevity·Carole GroussardNathalie Boisseau
Feb 21, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Nicole M GilbertsonSteven K Malin
Jul 26, 2019·Medicine and Science in Sports and Exercise·Edwin C ChinParco M Siu
Oct 15, 2019·Medicine and Science in Sports and Exercise·Natalie Z M EichnerSteven K Malin
Aug 21, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jose E Galgani, Rodrigo Fernández-Verdejo
Aug 28, 2020·Frontiers in Endocrinology·Steven K Malin, Nathan R Stewart

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