PMID: 7028922Oct 1, 1981Paper

Glucose transport and oxidation in adipose tissue of patients with myotonic dystrophy

Journal of the Neurological Sciences
E MablyA J Hudson

Abstract

The effect of insulin on the transport of 2-deoxyglucose and the oxidation of glucose in chopped adipose tissue was investigated in 14 myotonic dystrophy (MyD) patients and 28 age and size-matched control subjects. The transport of 0.55 mM 2-deoxyglucose was measured over 3 min at 37 degrees C both with and without 32 ng/ml of insulin. Oxidation was determined at 37 degrees C for 90 min by the measurement of 14CO2 released from a system containing 0.55 mM glucose with and without 50 ng/ml of insulin. Basal 2-deoxyglucose transport was not reduced in MyD subjects but insulin-stimulated 2-deoxyglucose transport in MyD was significantly less at 0.512 +/- 0.220 nmole compared to control subjects with 0.906 +/- 0.160 nmole/100 mg tissue/3 min (P less than 0.02). Both the basal and insulin-stimulated glucose oxidation were significantly less in the MyD group. Insulin-stimulated oxidation was 2.92 +/- 0.21 nmole in the control subjects compared to 2.20 +/- 0.27 nmole/100 mg tissue/90 min in the MyD cases (P less than 0.02). Similar findings were obtained when calculations were based on nmoles of 2-deoxyglucose transport and glucose oxidation/100 mg lipid. The findings indicate that both glucose transport and oxidation are impaired in ...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·M P Czech
May 1, 1979·Journal of the Neurological Sciences·A S HobbsB W Festoff
Mar 1, 1977·The Journal of Clinical Endocrinology and Metabolism·G J Tevaarwerk, A J Hudson
Aug 1, 1979·The Journal of Clinical Endocrinology and Metabolism·G J TevaarwerkA J Hudson
Jul 1, 1979·Annals of Neurology·B W Festoff, W V Moore
Feb 1, 1977·Canadian Journal of Biochemistry·B G Brenner, A Kahlenberg
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Sep 1, 1967·The Journal of Clinical Investigation·F A Gries, J Steinke

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Citations

Feb 1, 1983·Journal of the Neurological Sciences·L LamG J Tevaarwerk
Oct 1, 1986·Metabolism: Clinical and Experimental·W J KingstonR C Griggs
Sep 1, 1990·Metabolism: Clinical and Experimental·A J KrentzM Nattrass
Jun 1, 1986·Jinrui idengaku zasshi. The Japanese journal of human genetics·K OhnoK Takeshita
Feb 1, 1984·Annals of Neurology·R T MoxleyJ W Rowe
Dec 19, 2019·Frontiers in Neurology·Sylvia NieuwenhuisJeffrey C Glennon

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