Glucose transport in lactation

Advances in Experimental Medicine and Biology
P M Haney

Abstract

Lactose is the major carbohydrate of human milk and is also the major osmotic constituent of human milk. Therefore, synthesis of lactose is the major determinant of the volume of milk produced by the lactating human mammary gland. Lactose issynthesized from free glucose and UDP-galactose. Thus, glucose transport is required not only across the plasma membrane but also across an intracellular membrane to the compartment of lactose synthesis. The latter requirement is unique to mammary epithelial cells. Historically, based primarily on subcellular fractionation studies, lactose synthesis was thought to occur in Golgi. Yet, the only known glucose transporter isoform expressed in mammary gland is GLUT1, a plasma membrane glucose transporter. We therefore comprehensively studied the possible role of GLUT1 as a glucose transporter. We tested the hypothesis that changes in the amount, activity, and subcellular targeting of GLUT1 during lactation are consistent with an important role for GLUT1 in the regulation of lactation. The experiments described here summarize our recent work in the lactating mouse mammary gland and inmouse mammary epithelial cells in culture. Theresults demonstrate that GLUT1 is targeted to an intracellular compa...Continue Reading

Citations

Apr 29, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Laurie A Nommsen-RiversBin Huang
Jul 15, 2015·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Ronit LubetzkyDror Mandel

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