Glucose transport in lymphocytes.

Pflügers Archiv : European journal of physiology
Florian LangKarl S Lang

Abstract

Glucose uptake into lymphocytes is accomplished by non-concentrative glucose carriers of the GLUT family (GLUT1, GLUT3, GLUT4, GLUT6) and/or by the Na+-coupled glucose carrier SGLT1. The latter accumulates glucose against glucose gradients and is still effective at very low extracellular glucose concentrations. Signaling involved in SGLT1 expression and activity includes protein kinase A (PKA), protein kinase C (PKC), serum- and glucocorticoid-inducible kinase (SGK1), AMP-activated kinase (AMPK), and Janus kinases (JAK2 and JAK3). Glucose taken up is partially stored as glycogen. In hypoxic environments, such as in tumors as well as infected and inflamed tissues, lymphocytes depend on energy production from glycogen-dependent glycolysis. The lack of SGLT1 may compromise glycogen storage and thus lymphocyte survival and function in hypoxic tissues. Accordingly, in mice, genetic knockout of sglt1 compromised bacterial clearance following Listeria monocytogenes infection leading to an invariably lethal course of the disease. Whether the effect was due to the lack of sglt1 in lymphocytes or in other cell types still remains to be determined. Clearly, additional experimental effort is required to define the role of glucose transport...Continue Reading

References

Jan 1, 1991·The American Journal of Physiology·K MészárosJ J Spitzer
Sep 1, 1982·The Journal of Clinical Investigation·N Borregaard, T Herlin
Jun 21, 1996·The Journal of Biological Chemistry·J R HirschE M Wright
Feb 11, 1998·Physiological Reviews·F LangD Häussinger
Sep 8, 1998·The Biochemical Journal·M Matosin-MatekaloE Brot-Laroche
Aug 18, 2001·Japanese Journal of Cancer Research : Gann·N IshikawaN Kohno
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C C CaldwellM V Sitkovsky
Jul 30, 2002·Gynecologic Oncology·Luis E MendezMehrdad Nadji
May 16, 2003·Pflügers Archiv : European journal of physiology·Ernest M Wright, Eric Turk
Nov 12, 2003·American Journal of Clinical Pathology·Christian RudlowskiMarkus Moser
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth A Frauwirth, Craig B Thompson
Jun 3, 2004·Cancer Research·Rebecca L ElstromCraig B Thompson
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniel E BauerCraig B Thompson
Sep 17, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Brooke D HumphreyKirk C Klasing
Sep 25, 2004·Journal of Cellular Physiology·Maria L MachedaJames D Best
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn S JonesFrancis W Ruscetti
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Candace M Cham, Thomas F Gajewski
Oct 22, 2005·Nature Reviews. Immunology·Casey J FoxCraig B Thompson
Nov 2, 2005·Vascular Pharmacology·Radha AnanthakrishnanRavichandran Ramasamy
Aug 23, 2006·The Proceedings of the Nutrition Society·Emma H BakerBarbara J Philips
Oct 9, 2007·The International Journal of Biochemistry & Cell Biology·Guansong WangGuangyu Wu
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah R JacobsJeffrey C Rathmell
May 6, 2008·Cancer Cell·Jeffrey A Engelman, Lewis C Cantley
Jun 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark KiddRoswitha Pfragner
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marco PalazzoCristiano Rumio
Sep 16, 2008·European Journal of Immunology·Candace M ChamThomas F Gajewski
Oct 15, 2008·Cancer Investigation·Veerle F CasneufMarc Peeters
Nov 11, 2008·Pharmacology & Therapeutics·Vadivel GanapathyPuttur D Prasad
Dec 31, 2008·Journal of Cellular Biochemistry·Supriya SubramanianFrancisco Castaneda
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·John RoiniotisJohn A Hamilton
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan ZhengJonathan D Powell
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hidefumi KojimaTetsuji Kobata
Dec 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin DietlMarina P Kreutz
Feb 20, 2010·The Journal of Biological Chemistry·Thierry RoseJacques Thèze
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah R JacobsJeffrey C Rathmell
Mar 26, 2010·Molecular Membrane Biology·Mentor SopjaniFlorian Lang
May 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Juan-Carlos Rodríguez-PradosLisardo Boscá

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Citations

Aug 12, 2020·Pflügers Archiv : European journal of physiology·Hermann Koepsell, Volker Vallon
May 18, 2021·Frontiers in Molecular Biosciences·Qing-Hua LiuLiang Wang
Jun 3, 2021·International Journal of Molecular Sciences·George I LambrouApostolos Zaravinos
Jul 6, 2021·Frontiers in Cellular and Infection Microbiology·Xian WuYing-Chun Xu

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Methods Mentioned

BETA
genetic knockout

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